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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/78034
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dc.creatorBruna Rodrigues Dias Assispt_BR
dc.creatorValbert Nascimento Cardosopt_BR
dc.creatorÂngelo de Fátimapt_BR
dc.creatorFrederico Duarte Garciapt_BR
dc.creatorGisele Assis Castro Goulartpt_BR
dc.creatorMaila de Castro Lourenço das Nevespt_BR
dc.creatorPaulo Sérgio de Almeida Augustopt_BR
dc.creatorRaissa Lima Gonçalves Pereirapt_BR
dc.creatorSordaini Maria Caligiornipt_BR
dc.creatorBrian Sabatopt_BR
dc.creatorLarissa Pires do Espírito Santopt_BR
dc.creatorKarine Dias dos Reispt_BR
dc.creatorLeonardo da Silva Netopt_BR
dc.creatorSimone Odilia Antunes Fernandespt_BR
dc.date.accessioned2024-11-13T23:59:20Z-
dc.date.available2024-11-13T23:59:20Z-
dc.date.issued2023-
dc.citation.volume9pt_BR
dc.citation.spage100078pt_BR
dc.identifier.doiHttps://doi.org/10.1016/j.jciso.2023.100078pt_BR
dc.identifier.issn2666-934Xpt_BR
dc.identifier.urihttp://hdl.handle.net/1843/78034-
dc.description.resumoAnti-cocaine vaccines are a promising therapeutic strategy for treating cocaine use disorders. Here we hypothesize that nanoemulsions (NE) or suspensions (SS) loaded with the calix [4]arene-based immunogen UFMG-V4N2 can induce the production of anti-cocaine antibodies and decrease the passage of radiolabeled cocaine analog [99mTc]Trodat-1 through of the brain barrier. UFMG-V4N2 was characterized (solubility, morphology, DSC, XRD) and loaded into NEs and SSs using excipients approved for human use. Immunogenic efficacy was assessed by quantifying the titers and determining the specificity of anti-cocaine IgG antibodies, and by assessing the inhibition of [99mTc]Trodat-1 trafficking across the mice brain-barrier. UFMG-V4N2 is an amorphous, thermally stable molecule with very low hydrophilicity. The immunogenicity of NE or SS was similar, but aluminum phosphate and the lower dose of UFMG-V4N2 induced higher anti-cocaine IgG antibody titers, minimizing [99mTc]Trodat-1 uptake in the brain. Therefore, the UFMG-V4N2 may represent an alternative for the treatment of cocaine use disorder.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipOutra Agênciapt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTALpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJCIS Openpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectUFMG-V4N2pt_BR
dc.subjectCalix[4]arene-based immunogenpt_BR
dc.subjectPharmaceutical formulationpt_BR
dc.subjectAnti-cocaine therapypt_BR
dc.subject.otherCalixarenospt_BR
dc.subject.otherQuímica farmacêuticapt_BR
dc.subject.otherCocaínapt_BR
dc.subject.otherVacinaspt_BR
dc.titleLow doses of pharmaceutical formulations loaded with UFMG-V4N2 immunogen induce the production of IgG anti-cocaine antibodies and provide evidence of cerebral protection in the preclinical modelpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S2666934X23000053?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7597-9602pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2344-5590pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1926-9053pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0292-076Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4125-3736pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2303-4452pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4154-4237pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0825-7604pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7830-9882pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4554-9577pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6139-5187pt_BR
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