1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/78302
Registro completo de metadatos
Campo DCValorIdioma
dc.creatorLuiza Oliveira Peruccipt_BR
dc.creatorSirlaine Pio Gomes da Silvapt_BR
dc.creatorEduardo Bearzotipt_BR
dc.creatorKelerson Mauro de Castro Pintopt_BR
dc.creatorPatrícia Nessralla Alpoimpt_BR
dc.creatorMelina de Barros Pinheiropt_BR
dc.creatorLara Carvalho Godoipt_BR
dc.creatorLauro Ângelo Gonçalves de Moraespt_BR
dc.creatorLirlândia Pires de Sousapt_BR
dc.creatorLuci Maria Sant`Ana Dussept_BR
dc.creatorAndré Talvanipt_BR
dc.date.accessioned2024-11-26T23:05:28Z-
dc.date.available2024-11-26T23:05:28Z-
dc.date.issued2023-03-
dc.citation.volume228pt_BR
dc.citation.issue2pt_BR
dc.citation.spage1pt_BR
dc.citation.epage9pt_BR
dc.identifier.doi10.1016/j.imbio.2023.152339pt_BR
dc.identifier.issn0171-2985pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/78302-
dc.description.resumoAbstract Preeclampsia is a hypertensive disease of pregnancy associated with intense inflammatory and pro-coagulant responses. Neuroserpin is a serine protease inhibitor that has been involved in neurological and immune processes and has not yet been investigated in preeclampsia. Herein, we evaluated neuroserpin levels in association with other inflammatory mediators (IL-17A, IL-33, and CXCL-16) during severe preeclampsia. The mediators’ plasma levels were measured by immunoassays in 24 pregnant women with severe preeclampsia (early preeclampsia: N = 17, late preeclampsia: N = 7), 34 normotensive pregnant women, and 32 non-pregnant women. In general, pregnancy was associated with higher levels of neuroserpin, IL-17A, IL-33, and CXCL-16 than the non-pregnant state. However, this increase was attenuated in pregnancies complicated by severe preeclampsia. Although neuroserpin levels did not differ between normotensive pregnant women and pregnant women with severe preeclampsia, neuroserpin levels tended to be lower in early-onset than in late-onset severe preeclampsia. There were positive correlations between neuroserpin and IL-17A, neuroserpin and CXCL-16, and IL-17A and CXCL-16 levels in women with severe preeclampsia. In addition, although the risk for developing severe preeclampsia was higher in older women in this study, maternal age did not significantly influence the mediators’ levels, nor their correlations in the preeclampsia group. In summary, our data suggest that neuroserpin might be a potential biomarker for early-onset severe preeclampsia and, that the imbalance among neuroserpin, IL-17A, IL-33, and CXCL-16 levels may be associated with the pathogenesis of preeclampsia, regardless of the maternal age.pt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofImmunobiology-
dc.rightsAcesso Restritopt_BR
dc.subjectNeuroserpinapt_BR
dc.subjectInflamaçãopt_BR
dc.subjectPré-eclâmpsiapt_BR
dc.subjectBiomarcadorpt_BR
dc.subject.otherPré-eclâmpsiapt_BR
dc.subject.otherBiomarcadorpt_BR
dc.titleNeuroserpin: a potential biomarker for early-onset severe preeclampsiapt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0171298523000074?via%3Dihubpt_BR
Aparece en las colecciones:Artigo de Periódico

archivos asociados a este elemento:
no existem archivos asociados a este elemento.
Mostrar registro simple del elemento Visualizar estadísticas


Los elementos en el repositorio están protegidos por copyright, con todos los derechos reservados, salvo cuando es indicado lo contrario.