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Type:	Artigo de Periódico
Title:	Neuroserpin: a potential biomarker for early-onset severe preeclampsia
Authors:	Luiza Oliveira Perucci Sirlaine Pio Gomes da Silva Eduardo Bearzoti Kelerson Mauro de Castro Pinto Patrícia Nessralla Alpoim Melina de Barros Pinheiro Lara Carvalho Godoi Lauro Ângelo Gonçalves de Moraes Lirlândia Pires de Sousa Luci Maria Sant`Ana Dusse André Talvani
Abstract:	Abstract Preeclampsia is a hypertensive disease of pregnancy associated with intense inflammatory and pro-coagulant responses. Neuroserpin is a serine protease inhibitor that has been involved in neurological and immune processes and has not yet been investigated in preeclampsia. Herein, we evaluated neuroserpin levels in association with other inflammatory mediators (IL-17A, IL-33, and CXCL-16) during severe preeclampsia. The mediators’ plasma levels were measured by immunoassays in 24 pregnant women with severe preeclampsia (early preeclampsia: N = 17, late preeclampsia: N = 7), 34 normotensive pregnant women, and 32 non-pregnant women. In general, pregnancy was associated with higher levels of neuroserpin, IL-17A, IL-33, and CXCL-16 than the non-pregnant state. However, this increase was attenuated in pregnancies complicated by severe preeclampsia. Although neuroserpin levels did not differ between normotensive pregnant women and pregnant women with severe preeclampsia, neuroserpin levels tended to be lower in early-onset than in late-onset severe preeclampsia. There were positive correlations between neuroserpin and IL-17A, neuroserpin and CXCL-16, and IL-17A and CXCL-16 levels in women with severe preeclampsia. In addition, although the risk for developing severe preeclampsia was higher in older women in this study, maternal age did not significantly influence the mediators’ levels, nor their correlations in the preeclampsia group. In summary, our data suggest that neuroserpin might be a potential biomarker for early-onset severe preeclampsia and, that the imbalance among neuroserpin, IL-17A, IL-33, and CXCL-16 levels may be associated with the pathogenesis of preeclampsia, regardless of the maternal age.
Subject:	Pré-eclâmpsia Biomarcador
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS
Rights:	Acesso Restrito
metadata.dc.identifier.doi:	10.1016/j.imbio.2023.152339
URI:	http://hdl.handle.net/1843/78302
Issue Date:	Mar-2023
metadata.dc.url.externa:	https://www.sciencedirect.com/science/article/pii/S0171298523000074?via%3Dihub
metadata.dc.relation.ispartof:	Immunobiology
Appears in Collections:	Artigo de Periódico

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