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http://hdl.handle.net/1843/78640| Type: | Artigo de Periódico |
| Title: | An update on the current management of head and neck mucosal melanoma |
| Authors: | Ben Green Ahmed S. Elhamshary Ricardo Santiago Gomez Siavash Rahimi Peter A. Brennan |
| Abstract: | Primary mucosal melanomas of the head and neck are rare and aggressive tumours that arise in the nasal cavity, paranasal sinuses and more rarely in the oral cavity. The current treatment options include radical surgical resection with adjuvant external beam radiotherapy being offered in high-risk patients. Although the latter can improve regional control, it does not reduce overall survival. Elective neck dissection is recommended for nodular oral mucosal melanoma, but its role in the clinically node negative neck is controversial. Systemic therapies including the use of tyrosine kinase inhibitors for tumours with c-KIT mutations are suitable for patients with advanced loco-regional and/or metastatic disease, but current results are variable. Patients with head and neck mucosal melanoma have a poor prognosis due to the high incidence of metastatic disease. This review assesses the latest evidence in the diagnosis and management of primary oral and head and neck mucosal melanoma including details of systemic therapies. |
| Subject: | Radiotherapy Neoplasm staging Margins of excision Neoadjuvant therapy Radiotherapy, adjuvant Neoplasms Inhibitors, tyrosine kinase Stem cell factor Prognosis Diagnosis |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1111/jop.12526 |
| URI: | http://hdl.handle.net/1843/78640 |
| Issue Date: | 2017 |
| metadata.dc.url.externa: | https://onlinelibrary.wiley.com/doi/10.1111/jop.12526 |
| metadata.dc.relation.ispartof: | Journal of Oral Pathology & Medicine |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| An update on the current management of head and neck mucosal melanoma.pdf | 139.5 kB | Adobe PDF | View/Open |
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