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http://hdl.handle.net/1843/79338| Type: | Artigo de Periódico |
| Title: | First report of putative leishmania RNA virus 2 (LRV2) in Leishmania infantum strains from canine and human visceral leishmaniasis cases in the southeast of Brazil |
| Authors: | Felipe Dutra Rêgo Gabriela Araújo Vânia Lúcia Ribeiro da Matta Islam Hussein Chouman Thainá Bergantin Burrin Carmen m Sandoval Stella Maria Barrouin-melo Flaviane Alves de Pinho Hélida Monteiro de Andrade Ramon Vieira Nunes Célia Maria Ferreira Gontijo Eduardo Sérgio da Silva Vanete Thomaz Soccol Valeriana Valadares Lopes Rafael Gonçalves Teixeira-neto Vinícius Silva Belo Antônio Augusto Fonseca Júnior Diego Andrade Pereira Heber Paulino Pena Márcia Dalastra Laurenti |
| Abstract: | BACKGROUND: Leishmania RNA virus 1 (LRV1) is commonly found in South American Leishmania parasites belonging to the subgenus Viannia, whereas Leishmania RNA virus 2 (LRV2) was previously thought to be restricted to the Old-World pathogens of the subgenus Leishmania. OBJECTIVES: In this study, we investigated the presence of LRV2 in strains of Leishmania (L.) infantum, the causative agent of visceral leishmaniasis (VL), originating from different hosts, clinical forms, and geographical regions. METHODS: A total of seventy-one isolates were screened for LRV2 using semi-nested reverse transcription-polymerase chain reaction (RT-PCR) targeting the RNA-dependent RNA polymerase (RdRp) gene. FINDINGS: We detected LRV2 in two L. infantum isolates (CUR268 and HP-EMO) from canine and human cases, respectively. MAIN CONCLUSIONS: To the best of our knowledge, this is the first detection of LRV2 in the New World |
| Subject: | Leishmania Leishmaniose Biologia celular |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS ICB - DEPARTAMENTO DE PARASITOLOGIA |
| Rights: | Acesso Aberto |
| URI: | http://hdl.handle.net/1843/79338 |
| Issue Date: | 2023 |
| metadata.dc.url.externa: | https://www.arca.fiocruz.br/handle/icict/61381 |
| metadata.dc.relation.ispartof: | Memórias do Instituto Oswaldo Cruz |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| First report of putative Leishmania RNA virus 2 (1).pdf | 818.13 kB | Adobe PDF | View/Open |
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