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http://hdl.handle.net/1843/79381| Type: | Artigo de Periódico |
| Title: | Chronic alcohol administration alters metabolomic profile of murine bone marrow |
| Authors: | Tássia Tatiane Pontes Pereira Ernani Pinto Ricardo Santiago Gomez Mauro Martins Teixeira Adriana Nori de Macedo Gisele André Baptista Canuto Frederico Marianetti Soriani Filipe Fideles Duarte-andrade Jéssica Gardone Vitório Taiane do Espírito Santo Pereira Flavia Rayssa Braga Martins Jéssica Amanda Marques Souza Nathália Luisa Malacco Eliza Mathias Melo Carolina Raíssa Costa Picossi |
| Abstract: | Introduction: People with hazardous alcohol use are more susceptible to viral, bacterial, and fungal infections due to the effect of alcohol on immune system cell function. Metabolized ethanol reduces NAD+ to NADH, affecting critical metabolic pathways. Here, our aim was to investigate whether alcohol is metabolized by bone marrow cells and if it impacts the metabolic pathways of leukocyte progenitor cells. This is said to lead to a qualitative and quantitative alteration of key metabolites which may be related to the immune response. Methods: We addressed this aim by using C57BL/6 mice under chronic ethanol administration and evaluating the metabolomic profile of bone marrow total cells by gas chromatography–coupled mass spectrometry (GC–MS). Results: We identified 19 metabolites. Our data demonstrated that chronic ethanol administration alters the metabolomic profile in the bone marrow, resulting in a statistically diminished abundance of five metabolites in ethanoltreated animals: uracil, succinate, proline, nicotinamide, and tyrosine. Discussion: Our results demonstrate for the first time in the literature the effects of alcohol consumption on the metabolome content of hematopoietic tissue and open a wide range of further studies to investigate mechanisms by which alcohol compromises the cellular function of the immune system. |
| Subject: | Alcoolismo Álcool no organismo Metabólitos Sistema imunológico Células da medula óssea |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICX - DEPARTAMENTO DE QUÍMICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.3389/fimmu.2023.1128352 |
| URI: | http://hdl.handle.net/1843/79381 |
| Issue Date: | 5-Apr-2023 |
| metadata.dc.url.externa: | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1128352/full |
| metadata.dc.relation.ispartof: | Frontiers in Immunology |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Chronic alcohol administration alters metabolomic profile of murine bone marrow.pdf | 722.76 kB | Adobe PDF | View/Open |
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