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http://hdl.handle.net/1843/79412| Tipo: | Artigo de Periódico |
| Título: | Congenital zika syndrome is associated with maternal protein malnutrition |
| Autor(es): | Jimena Barbeito Andrés A. D. Rossi Rodrigo V. Barbosa C. K. N. Amorim Michel. P. C. de Souza Leila Chimelli Renato Santana de Aguiar Paula N. Gonzalez Flávio Alves Lara Márcia C. Castro Zoltán Molnár Paula Pezzuto Ricardo Tadeu Lopes Marcelo T. Bozza João Lídio Vianez Júnior C. G. Barbeito Patricia Cuervo Maria Bellio Amilcar Tanuri Patricia P. Garcez Luiza M. Higa André Alves Dias Janaina Vasconcelos T. M. P. Santos Jessica C. C. G. Ferreira Raiane O. Ferreira F. F. Dutra |
| Resumo: | Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments knownas congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggestingthat its occurrence could depend on cofactors. Here, we evaluate the relevance of protein malnutrition for theemergence of CZS. Epidemiological data from the ZIKV outbreak in the Americas suggest a relationship betweenundernutrition and cases of microcephaly. To experimentally examine this relationship, we use immunocompetentpregnant mice, which were subjected to protein malnutrition and infected with a Brazilian ZIKV strain. We foundthat the combination of protein restriction and ZIKV infection leads to severe alterations of placental structure andembryonic body growth, with offspring displaying a reduction in neurogenesis and postnatal brain size. RNA-seqanalysis reveals gene expression deregulation required for brain development in infected low-protein progeny.These results suggest that maternal protein malnutrition increases susceptibility to CZS. |
| Assunto: | Vírus da Zika Gravidez Genética |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | ICB - INSTITUTO DE CIÊNCIAS BIOLOGICAS |
| Tipo de Acesso: | Acesso Aberto |
| Identificador DOI: | https://DOI.10.1126/sciadv.aaw6284 |
| URI: | http://hdl.handle.net/1843/79412 |
| Data do documento: | 10-Jan-2020 |
| metadata.dc.url.externa: | https://www.science.org/doi/10.1126/sciadv.aaw6284 |
| metadata.dc.relation.ispartof: | Science Advances |
| Aparece nas coleções: | Artigo de Periódico |
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| Arquivo | Descrição | Tamanho | Formato | |
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| Congenital Zika syndrome is associated with maternalprotein malnutrition.pdf | 1.25 MB | Adobe PDF | Visualizar/Abrir |
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