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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/79415
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dc.creatorNuno Fariapt_BR
dc.creatorJohn McCronept_BR
dc.creatorRuben Hulswitpt_BR
dc.creatorLucas Francopt_BR
dc.creatorMariana Ramundopt_BR
dc.creatorJaqueline de Jesuspt_BR
dc.creatorPamela. Andradept_BR
dc.creatorThais Colettipt_BR
dc.creatorGiulia Ferreirapt_BR
dc.creatorCamila Silvapt_BR
dc.creatorErika Manulipt_BR
dc.creatorThomas Mellanpt_BR
dc.creatorRafael Pereirapt_BR
dc.creatorPedro Peixotopt_BR
dc.creatorMoritz Kraemerpt_BR
dc.creatorNelson Gaburopt_BR
dc.creatorCecilia da Camilopt_BR
dc.creatorHenrique Hoeltgebaumpt_BR
dc.creatorWilliam Souzapt_BR
dc.creatorEsmenia Rochapt_BR
dc.creatorLeandro de Souzapt_BR
dc.creatorMariana de Pinhopt_BR
dc.creatorCharles Whittakerpt_BR
dc.creatorLeonardo Araujopt_BR
dc.creatorFrederico Maltapt_BR
dc.creatorAline de Limapt_BR
dc.creatorJoice do Silvapt_BR
dc.creatorDanielle Zaulipt_BR
dc.creatorAlessandro de Ferreirapt_BR
dc.creatorRicardo Schnekenbergpt_BR
dc.creatorDaniel Laydonpt_BR
dc.creatorPatrick Walkerpt_BR
dc.creatorHannah Schlüterpt_BR
dc.creatorIngra Claropt_BR
dc.creatorAna dos Santospt_BR
dc.creatorMaria Vidalpt_BR
dc.creatorValentina Del Caropt_BR
dc.creatorRosinaldo Filhopt_BR
dc.creatorHelem Dos Santospt_BR
dc.creatorRenato Santana de Aguiarpt_BR
dc.creatorJosé Proença-Modenapt_BR
dc.creatorBruce Nelsonpt_BR
dc.creatorJames Haypt_BR
dc.creatorMélodie Monodpt_BR
dc.creatorDarlan da Candidopt_BR
dc.creatorXenia Miscouridoupt_BR
dc.creatorHelen Couplandpt_BR
dc.creatorRaphael Sonabendpt_BR
dc.creatorMichaela Vollmerpt_BR
dc.creatorAxel Gandypt_BR
dc.creatorCarlos Pretept_BR
dc.creatorVitor Nascimentopt_BR
dc.creatorMarc Suchardpt_BR
dc.creatorThomas Bowdenpt_BR
dc.creatorSergei Pondpt_BR
dc.creatorSwapnil Mishrapt_BR
dc.creatorChieh-hsi Wupt_BR
dc.creatorOliver Ratmannpt_BR
dc.creatorNeil Fergusonpt_BR
dc.creatorChristopher Dyept_BR
dc.creatorNick Lomanpt_BR
dc.creatorPhilippe Lemeypt_BR
dc.creatorAndrew Rambautpt_BR
dc.creatorNelson Fraijipt_BR
dc.creatorMaria do Carvalhopt_BR
dc.creatorOliver Pybuspt_BR
dc.creatorMyuki Crispimpt_BR
dc.creatorSeth Flaxmanpt_BR
dc.creatorSamir Bhattpt_BR
dc.creatorEster Sabinopt_BR
dc.creatorFlavia Salespt_BR
dc.creatorIwona Hawrylukpt_BR
dc.date.accessioned2025-01-22T21:19:11Z-
dc.date.available2025-01-22T21:19:11Z-
dc.date.issued2021-04-14-
dc.citation.volume372pt_BR
dc.citation.spage815pt_BR
dc.citation.epage821pt_BR
dc.identifier.doihttps:// doi:10.1126/science.abh2644pt_BR
dc.identifier.issn0036-8075pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/79415-
dc.description.resumoCases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Manaus, Brazil,resurged in late 2020 despite previously high levels of infection. Genome sequencing of viruses sampledin Manaus between November 2020 and January 2021 revealed the emergence and circulation of anovel SARS-CoV-2 variant of concern. Lineage P.1 acquired 17 mutations, including a trio in thespike protein (K417T, E484K, and N501Y) associated with increased binding to the human ACE2(angiotensin-converting enzyme 2) receptor. Molecular clock analysis shows that P.1 emergenceoccurred around mid-November 2020 and was preceded by a period of faster molecular evolution. Usinga two-category dynamical model that integrates genomic and mortality data, we estimate that P.1may be 1.7- to 2.4-fold more transmissible and that previous (non-P.1) infection provides 54 to 79% ofthe protection against infection with P.1 that it provides against non-P.1 lineages. Enhanced globalgenomic surveillance of variants of concern, which may exhibit increased transmissibility and/or immuneevasion, is critical to accelerate pandemic responsiveness.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofSciencept_BR
dc.rightsAcesso Abertopt_BR
dc.subject.otherCOVID-19 (Doença)pt_BR
dc.subject.otherSARS-CoV-2pt_BR
dc.subject.otherPandemiapt_BR
dc.subject.otherMicrobiologiapt_BR
dc.titleGenomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazilpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.science.org/doi/full/10.1126/science.abh2644?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.orgpt_BR
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