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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/79442
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dc.creatorJoice do Prado Silvapt_BR
dc.creatorLuíza Campos Guerra de Araújo e Santospt_BR
dc.creatorAlessandro Clayton de Souza Ferreirapt_BR
dc.creatorRenan Pedra de Souzapt_BR
dc.creatorRenato Santana de Aguiarpt_BR
dc.creatorDanielle Alves Gomes Zaulipt_BR
dc.creatorAline Brito de Limapt_BR
dc.creatorLuige Biciati Alvimpt_BR
dc.creatorFrederico Scott Varella Maltapt_BR
dc.creatorCristiane Pinheiro Toscano Brito Mendonçapt_BR
dc.creatorAndré Henrique Barbosa de Carvalhopt_BR
dc.creatorJéssica Silqueira Hickson Riospt_BR
dc.creatorPaula Luize Camargos Fonsecapt_BR
dc.creatorDaniel Costa Queirozpt_BR
dc.date.accessioned2025-01-23T20:54:45Z-
dc.date.available2025-01-23T20:54:45Z-
dc.date.issued2023-04-20-
dc.citation.volume15pt_BR
dc.citation.issue4pt_BR
dc.citation.spage1pt_BR
dc.citation.epage15pt_BR
dc.identifier.doihttps://doi.org/10.3390/v15041017pt_BR
dc.identifier.issn1999-4915pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/79442-
dc.description.resumoThe introduction of SARS-CoV-2 variants of concern (VOCs) in Brazil has been associated with major impacts on the epidemiological and public health scenario. In this study, 291,571 samples were investigated for SARS-CoV-2 variants from August 2021 to March 2022 (the highest peak of positive cases) in four geographical regions of Brazil. To identify the frequency, introduction, and dispersion of SARS-CoV-2 variants in 12 Brazilian capitals, VOCs defining spike mutations were identified in 35,735 samples through genotyping and viral genome sequencing. Omicron VOC was detected in late November 2021 and replaced the Delta VOC in approximately 3.5 weeks. We estimated viral load differences between SARS-CoV-2 Delta and Omicron through the evaluation of the RT-qPCR cycle threshold (Ct) score in 77,262 samples. The analysis demonstrated that the Omicron VOC has a lower viral load in infected patients than the Delta VOC. Analyses of clinical outcomes in 17,586 patients across the country indicated that individuals infected with Omicron were less likely to need ventilatory support. The results of our study reinforce the importance of surveillance programs at the national level and showed the introduction and faster dispersion of Omicron over Delta VOC in Brazil without increasing the numbers of severe cases of COVID-19.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - INSTITUTO DE CIÊNCIAS BIOLOGICASpt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofVirusespt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectSARS-CoV-2pt_BR
dc.subjectVariantspt_BR
dc.subjectEpidemiologic surveillancept_BR
dc.subjectCOVID-19pt_BR
dc.subjectViral loadpt_BR
dc.subjectSymptomspt_BR
dc.subject.otherSARS-CoV-2pt_BR
dc.subject.otherCOVID-19pt_BR
dc.subject.otherEpidemiologiapt_BR
dc.subject.otherEpidemiaspt_BR
dc.subject.otherPandemiaspt_BR
dc.titleEpidemiological surveillance reveals the rise and establishment of the omicron SARS-CoV-2 variant in Brazilpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.mdpi.com/1999-4915/15/4/1017pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9553-4328pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5180-3717pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6607-8818pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6192-3587pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3432-8146pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9495-0987pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7031-2902pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8103-9235pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9479-4432pt_BR
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