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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/79648
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dc.creatorFernanda Borattopt_BR
dc.creatorEduardo Lagespt_BR
dc.creatorCristina Lourespt_BR
dc.creatorAdriano Sabinopt_BR
dc.creatorAngelo Malachiaspt_BR
dc.creatorDanyelle Townsendpt_BR
dc.creatorAndré Luís Branco de Barrospt_BR
dc.creatorLucas Antonio Miranda Ferreirapt_BR
dc.creatorElaine Amaral Leitept_BR
dc.date.accessioned2025-02-04T16:40:38Z-
dc.date.available2025-02-04T16:40:38Z-
dc.date.issued2023-06-23-
dc.citation.volume165pt_BR
dc.citation.spage01pt_BR
dc.citation.epage08pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.biopha.2023.115034pt_BR
dc.identifier.issn0753-3322pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/79648-
dc.description.resumoLiposomes composed of a rigid bilayer have high plasma stability; however, they can be challenged in efficacy due to complications in releasing the encapsulated drug as well as being internalized by the tumor cell. On the other hand, fusogenic liposomes may fuse with the plasmatic membrane and release encapsulated material directly into the cytoplasm. In a previous study, fusogenic liposomes composed of alpha-tocopheryl succinate (TS) and doxorubicin (DOX) were developed (pHSL-TS-DOX). These stabilized tumor growth and reduced toxicity compared to a commercial formulation. In the present study, we investigated whether cellular uptake or DOX accumulation in the tumor could justify the better performance of the pHSL-TS-DOX formulation. Release, deformability, and DOX plasmatic concentration studies were also carried out. pHSL-TS-DOX showed an adequate release profile and demonstrated characteristics of a deformable formulation. Data from apoptosis, cell cycle, and nuclear morphology studies have shown that the induction of cell death caused by pHSL-TS-DOX occurred more quickly. Higher DOX cellular uptake and tumor accumulation were observed when pHSL-TSDOX was administered, demonstrating better drug delivery capacity. Therefore, better DOX uptake as well as tumor accumulation explain the great antitumor activity previously demonstrated for this formulation.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOSpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE FÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBiomedicine & Pharmacotherapypt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectDoxorubicinpt_BR
dc.subjectAlpha-tocopheryl succinatept_BR
dc.subjectPH-sensitive liposomespt_BR
dc.subjectTumor accumulationpt_BR
dc.subjectBreast cancerpt_BR
dc.subject.otherCâncerpt_BR
dc.subject.otherTumorespt_BR
dc.subject.otherBiologia celular e molecularpt_BR
dc.titleAlpha-tocopheryl succinate and doxorubicin-loaded liposomes improve drug uptake and tumor accumulation in a murine breast tumor modelpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0753332223008247pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6704-4057pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2912-5312pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8562-8689pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8703-4283pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7979-1156pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4782-5416pt_BR
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