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Type:	Artigo de Periódico
Title:	Potential role of vacuumassisted procedures in resecting breast cancers and highlighting selection criteria to support future trials
Authors:	Carolina Nazareth Valadares Henrique Lima Couto Aleida Nazareth Soares Paola Hartung Toppa Bernardo Ricardo Stuart Mcintosh Nisha Sharma Vivian Resende
Abstract:	Purpose: The purpose of this study was to evaluate the role of vacuum-assisted biopsy (VAB) in resecting breast cancers. Methods: Retrospective database analysis of 116 cancers [both invasive breast cancers (IC) and ductal carcinoma in situ (DCIS)] diagnosed by VAB submitted to standard surgical treatment with complete histological data from VAB and surgery. Excision following VAB was defined as complete resection (CR) if there was no residual tumor in the surgical specimen, minimal residual disease (MRD) if residual tumor ≤ 3 mm, gross residual disease (GRD) if residual tumor > 3 mm, and upgrade from DCIS on VAB to IC. CR and MRD were combined as potentially resected percutaneously (PRP). GRD and those with upgrade to IC were determined not eligible for percutaneous resection (NPR). Factors predictive of PRP were evaluated. Results: Mean age was 55.6 years (20–91; SD: 12,27). CR was seen in 29 of 116 cases (25%), MRD in 18 of 116 cases (15.5%), GRD in 64 of 116 cases (55.2%), and five of 116 cases (4.3%) were upgraded from DCIS to IC, and those groups combined represented 47 cases of PRP (40.5%) and 69 (59,5%) of NPR. For 77 tumors ≤ 10 mm, 45 (58.5%) were PRP. Multivariate analysis reveals significance for enlarged VAB (EVAB) (p = 0.008, OR: 4.4, 95% CI), low/intermediate nuclear grade (p < 0.001, OR: 12.5, 95% CI) and final tumor size (T) ≤ 10 mm (p = 0.001, OR: 50.1, 95% CI) for PRP. Conclusions: This study showed that lesions completely excised with VAB that were cancer could have been treated with VAB rather than surgery but tumor selection in terms of subtype and size is important.
Subject:	Câncer Biopsia Procedimentos minimamente invasivos
language:	eng
metadata.dc.publisher.country:	Brasil
Publisher:	Universidade Federal de Minas Gerais
Publisher Initials:	UFMG
metadata.dc.publisher.department:	ICB - DEPARTAMENTO DE MORFOLOGIA MED - DEPARTAMENTO DE CIRURGIA
Rights:	Acesso Aberto
metadata.dc.identifier.doi:	https://doi.org/10.3389/fonc.2023.1239574
URI:	http://hdl.handle.net/1843/79690
Issue Date:	21-Sep-2023
metadata.dc.url.externa:	https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1239574/full
metadata.dc.relation.ispartof:	Frontiers in Oncology
Appears in Collections:	Artigo de Periódico

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