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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/79769
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Campo DCValorIdioma
dc.creatorGeraldo Célio Brandãopt_BR
dc.creatorErna Geessien Kroonpt_BR
dc.creatorJosé Souza Filhopt_BR
dc.creatorAlaíde Braga Oliveirapt_BR
dc.date.accessioned2025-02-07T21:07:10Z-
dc.date.available2025-02-07T21:07:10Z-
dc.date.issued2017-05-29-
dc.citation.volume2017pt_BR
dc.citation.spage1pt_BR
dc.citation.epage11pt_BR
dc.identifier.doihttps://doi.org/10.1155/2017/6106959pt_BR
dc.identifier.issn1687-9686pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/79769-
dc.description.resumoA phytochemical study of Fridericia formosa (Bignoniaceae) ethanol extracts of leaves, stems, and fruits was guided by in vitro assays against vaccinia virus Western Reserve (VACV-WR), human herpes virus 1 (HSV-1), murine encephalomyocarditis virus (EMCV), and dengue virus type 2 (DENV-2) by the MTT method. All the ethanol extracts were active against DENV-2, HSV-1, and VACV-WR with best results for the fruits extract against DENV-2 (SI > 38.2). For VACV-WR and HSV-1, EC50 values > 200 μg mL−1 were determined, while no inhibition of the cytopathic effect was observed with EMCV. Five compounds were isolated and identified as the C-glucosylxanthones mangiferin (1), 2′-O-trans-caffeoylmangiferin (2), 2′-O-trans-coumaroylmangiferin (3), 2′-O-trans-cinnamoylmangiferin (5), and the flavonoid chrysin (4). The most active compound was 2′-O-trans-coumaroylmangiferin (3) with SI > 121.9 against DENV-2 and 108.7 for HSV-1. These results indicate that mangiferin cinnamoyl esters might be potential antiviral drugs.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of Tropical Medicinept_BR
dc.rightsAcesso Abertopt_BR
dc.subjectBignoniaceapt_BR
dc.subjectAgentes antiviraispt_BR
dc.subject.otherBignoniaceapt_BR
dc.subject.otherAgentes antiviraispt_BR
dc.subject.otherVírus da denguept_BR
dc.subject.otherHerpesvíruspt_BR
dc.titleAntiviral activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) extracts and constituentspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/epdf/10.1155/2017/6106959pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7330-051Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2721-3826pt_BR
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