Please use this identifier to cite or link to this item:
http://hdl.handle.net/1843/79895| Type: | Artigo de Periódico |
| Title: | Evidence of natural Zika virus infection in neotropical non-human primates in Brazil |
| Authors: | Ana Carolina Terzian Nathalia Zini Lívia Sacchetto Rebeca Froes Rocha Maisa Carla Pereira Parra Juliana Lemos Del Sarto Ana Carolina Fialho Dias Felipe Coutinho Jéssica Rayra Rafael Alves da Silva Vivian Vasconcelos Costa Natália Coelho Couto de Azevedo Fernandes Rodrigo Réssio Josué Díaz-Delgado Juliana Guerra Mariana Cunha José Luiz Catão-Dias Cintia Bittar Andréia Francesli Negri Reis Izalco Nuremberg Penha dos Santos Andréia Cristina Marascalchi Ferreira Lilian Elisa Arão Antônio Cruz Paula Rahal Leila Ullmann Camila Malossi João Pessoa de Araújo Steven Widen Izabela Maurício de Rezende Érica Mello Carolina Colombelli Pacca Erna Geessien Kroon Giliane Trindade Betânia Drumond Francisco Chiaravalloti-Neto Nikos Vasilakis Mauro Teixeira Maurício Lacerda Nogueira |
| Abstract: | In Africa, Old World Primates are involved in the maintenance of sylvatic circulation of ZIKV. However, in Brazil, the hosts for the sylvatic cycle remain unknown. We hypothesized that free-living NHPs might play a role in urban/periurban ZIKV dynamics, thus we undertook an NHP ZIKV investigation in two cities in Brazil. We identified ZIKV-positive NHPs and sequences obtained were phylogenetically related to the American lineage of ZIKV. Additionally, we inoculated four C. penicillata with ZIKV and our results demonstrated that marmosets had a sustained viremia. The natural and experimental infection of NHPs with ZIKV, support the hypothesis that NHPs may be a vertebrate host in the maintainance of ZIKV transmission/circulation in urban tropical settings. Further studies are needed to understand the role they may play in maintaining the urban cycle of the ZIKV and how they may be a conduit in establishing an enzootic transmission cycle in tropical Latin America. |
| Subject: | Vírus da Zika Animais - Doenças Primatas Infecções pelo Zika vírus |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA ICB - DEPARTAMENTO DE FARMACOLOGIA ICB - DEPARTAMENTO DE MICROBIOLOGIA ICB - DEPARTAMENTO DE MORFOLOGIA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | https://doi.org/10.1038/s41598-018-34423-6 |
| URI: | http://hdl.handle.net/1843/79895 |
| Issue Date: | 30-Oct-2018 |
| metadata.dc.url.externa: | https://www.nature.com/articles/s41598-018-34423-6#article-info |
| metadata.dc.relation.ispartof: | Scientific Reports |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Evidence of natural Zika virus infection in neotropical non-human primates in Brazil.pdf | 2.71 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.