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http://hdl.handle.net/1843/79929| Tipo: | Artigo de Periódico |
| Título: | Late-relapsing hepatitis after yellow fever |
| Autor(es): | Izabela Maurício Rezende Leonardo Soares Pereira Jordana Rodrigues Barbosa Fradico Marcelo Antônio Pascoal Xavier Pedro Augusto Alves Ana Carolina Campi-Azevedo Elaine Speziali Lívia Zignago Moreira dos Santos Natalia Soares Albuquerque Indiara Penido Tayrine Araujo Santos Ana Paula Dinis Ano Bom Andrea Marques Vieira da Silva Camilla Bayma Fernandes Carlos Eduardo Calzavara Erna Geessien Kroon Olindo Assis Martins-Filho Andréa Teixeira-Carvalho Betânia Paiva Drumond |
| Resumo: | One patient presented hyporexia, asthenia, adynamia, and jaundice two months after acute yellow fever (YF) onset; plus laboratory tests indicating hepatic cytolysis and a rebound of alanine and aspartate transaminases, and total and direct bilirubin levels. Laboratory tests discarded autoimmune hepatitis, inflammatory or metabolic liver disease, and new infections caused by hepatotropic agents. Anti-YFV IgM, IgG and neutralizing antibodies were detected in different times, but no viremia. A liver biopsy was collected three months after YF onset and tested positive for YFV antigens and wild-type YFV-RNA (364 RNA-copies/gram/liver). Transaminases and bilirubin levels remained elevated for five months, and the arresting of symptoms persisted for six months after the acute YF onset. Several serum chemokines, cytokines, and growth factors were measured. A similar immune response profile was observed in the earlier phases of the disease, followed by more pronounced changes in the later stages, when transaminases levels returned to normal. The results indicated viral persistence in the liver and continual liver cell damage three months after YF onset and reinforced the need for extended follow-ups of YF patients. Further studies to investigate the role of possible viral persistence and the immune response causing relapsing hepatitis following YF are also necessary. |
| Assunto: | Vírus da Febre Amarela Hepatite Flavivirus |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | ICB - DEPARTAMENTO DE MICROBIOLOGIA MED - DEPARTAMENTO DE ANATOMIA PATOLÓGICA E MEDICINA LEGAL |
| Tipo de Acesso: | Acesso Aberto |
| Identificador DOI: | https://doi.org/10.3390/v12020222 |
| URI: | http://hdl.handle.net/1843/79929 |
| Data do documento: | 17-Fev-2020 |
| metadata.dc.url.externa: | https://www.mdpi.com/1999-4915/12/2/222 |
| metadata.dc.relation.ispartof: | Viruses |
| Aparece nas coleções: | Artigo de Periódico |
Arquivos associados a este item:
| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Late-relapsing hepatitis after yellow fever.pdf | 1.8 MB | Adobe PDF | Visualizar/Abrir |
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