1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/80366
Registro completo de metadatos
Campo DCValorIdioma
dc.creatorRaquel Duque do Nascimento Arifapt_BR
dc.creatorMauro Martins Teixeirapt_BR
dc.creatorCaio Tavares Fagundespt_BR
dc.creatorDaniele da Glória de Souzapt_BR
dc.creatorTalles Prosperi de Paulapt_BR
dc.creatorRenata Lacerda de Limapt_BR
dc.creatorCamila Bernardo de Britopt_BR
dc.creatorMaria Emília Rabelo Andradept_BR
dc.creatorValbert Nascimento Cardosopt_BR
dc.creatorMauricio Veloso Brant Pinheiropt_BR
dc.creatorLuiz Orlando Ladeirapt_BR
dc.creatorKlaus Wilhelm Heinrich Krambrockpt_BR
dc.date.accessioned2025-02-24T18:34:19Z-
dc.date.available2025-02-24T18:34:19Z-
dc.date.issued2021-
dc.citation.volume898pt_BR
dc.citation.spage1pt_BR
dc.citation.epage9pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.ejphar.2021.173984pt_BR
dc.identifier.issn0014-2999pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/80366-
dc.description.resumoIntestinal ischemia is a vascular emergency that arises when blood flow to the intestine is compromised. Reperfusion is necessary to restore intestinal function but might lead to local and systemic inflammatory responses and bacterial translocation, with consequent multiple organ dysfunction syndrome (MODS). During reperfusion occurs production of reactive oxygen species. These species contribute to intestinal injury through direct toxicity or activation of inflammatory pathways. Fullerol is a nanacomposite which has been shown to act as reactive oxygen species and reactive nitrogen species (RNS) scavengers. Thus, our aim was to evaluate whether Fullerol confer anti-inflammatory activity during intestinal ischemia and reperfusion (IIR). Intestinal ischemia was induced by total occlusion of the superior mesenteric artery. Groups were treated with vehicle or Fullerol 10 min before reperfusion. Mice were euthanized after 6 h of reperfusion, and small intestines were collected for evaluation of plasma extravasation, leukocyte influx, cytokine production and histological damage. Bacterial translocation to the peritoneal cavity and reactive oxygen and nitrogen species production by lamina propria cells were also evaluated. Our results showed that treatment with Fullerol inhibited bacterial translocation to the peritoneal cavity, delayed and decreased the lethality rates and diminished neutrophil influx and intestinal injury induced by IIR. Reduced severity of reperfusion injury in Fullerol-treated mice was associated with blunted reactive oxygen and nitrogen species production in leukocytes isolated from gut lamina propria and decreased production of pro-inflammatory mediators. Thus, the present study shows that Fullerol is a potential therapy to treat inflammatory bowel disorders associated with bacterial translocation, such as IIR.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)pt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentENG - DEPARTAMENTO DE ENGENHARIA QUÍMICApt_BR
dc.publisher.departmentFAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICASpt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FARMACOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MICROBIOLOGIApt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE FÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofEuropean Journal of Pharmacologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectIntestinal ischemia and reperfusionpt_BR
dc.subjectFullerolpt_BR
dc.subjectNanocompositept_BR
dc.subjectReactive oxygen speciespt_BR
dc.subject.otherIsquemia intestinalpt_BR
dc.subject.otherReperfusãopt_BR
dc.subject.otherFulerolpt_BR
dc.subject.otherNanocompósitospt_BR
dc.titleAnti-inflammatory and antioxidant effects of the nanocomposite Fullerol decrease the severity of intestinal inflammation induced by gut ischemia and reperfusionpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0014299921001370?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0888-2282pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6944-3008pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6747-5233pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7478-5934pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3120-5183pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4571-7238pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7597-9602pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5722-6260pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4935-6070pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7562-0285pt_BR
Aparece en las colecciones:Artigo de Periódico

archivos asociados a este elemento:
no existem archivos asociados a este elemento.
Mostrar registro simple del elemento Visualizar estadísticas


Los elementos en el repositorio están protegidos por copyright, con todos los derechos reservados, salvo cuando es indicado lo contrario.