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http://hdl.handle.net/1843/80366| Tipo: | Artigo de Periódico |
| Título: | Anti-inflammatory and antioxidant effects of the nanocomposite Fullerol decrease the severity of intestinal inflammation induced by gut ischemia and reperfusion |
| Autor(es): | Raquel Duque do Nascimento Arifa Mauro Martins Teixeira Caio Tavares Fagundes Daniele da Glória de Souza Talles Prosperi de Paula Renata Lacerda de Lima Camila Bernardo de Brito Maria Emília Rabelo Andrade Valbert Nascimento Cardoso Mauricio Veloso Brant Pinheiro Luiz Orlando Ladeira Klaus Wilhelm Heinrich Krambrock |
| Resumen: | Intestinal ischemia is a vascular emergency that arises when blood flow to the intestine is compromised. Reperfusion is necessary to restore intestinal function but might lead to local and systemic inflammatory responses and bacterial translocation, with consequent multiple organ dysfunction syndrome (MODS). During reperfusion occurs production of reactive oxygen species. These species contribute to intestinal injury through direct toxicity or activation of inflammatory pathways. Fullerol is a nanacomposite which has been shown to act as reactive oxygen species and reactive nitrogen species (RNS) scavengers. Thus, our aim was to evaluate whether Fullerol confer anti-inflammatory activity during intestinal ischemia and reperfusion (IIR). Intestinal ischemia was induced by total occlusion of the superior mesenteric artery. Groups were treated with vehicle or Fullerol 10 min before reperfusion. Mice were euthanized after 6 h of reperfusion, and small intestines were collected for evaluation of plasma extravasation, leukocyte influx, cytokine production and histological damage. Bacterial translocation to the peritoneal cavity and reactive oxygen and nitrogen species production by lamina propria cells were also evaluated. Our results showed that treatment with Fullerol inhibited bacterial translocation to the peritoneal cavity, delayed and decreased the lethality rates and diminished neutrophil influx and intestinal injury induced by IIR. Reduced severity of reperfusion injury in Fullerol-treated mice was associated with blunted reactive oxygen and nitrogen species production in leukocytes isolated from gut lamina propria and decreased production of pro-inflammatory mediators. Thus, the present study shows that Fullerol is a potential therapy to treat inflammatory bowel disorders associated with bacterial translocation, such as IIR. |
| Asunto: | Isquemia intestinal Reperfusão Fulerol Nanocompósitos |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Institución: | UFMG |
| Departamento: | ENG - DEPARTAMENTO DE ENGENHARIA QUÍMICA FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS ICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA ICB - DEPARTAMENTO DE FARMACOLOGIA ICB - DEPARTAMENTO DE MICROBIOLOGIA ICX - DEPARTAMENTO DE FÍSICA |
| Tipo de acceso: | Acesso Restrito |
| Identificador DOI: | https://doi.org/10.1016/j.ejphar.2021.173984 |
| URI: | http://hdl.handle.net/1843/80366 |
| Fecha del documento: | 2021 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0014299921001370?via%3Dihub |
| metadata.dc.relation.ispartof: | European Journal of Pharmacology |
| Aparece en las colecciones: | Artigo de Periódico |
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