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Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/80467
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dc.creatorEssam.A.al-Moraissipt_BR
dc.creatorA. Kaurpt_BR
dc.creatorRicardo Santiago Gomezpt_BR
dc.creatorE. Ellispt_BR
dc.date.accessioned2025-02-26T17:39:39Z-
dc.date.available2025-02-26T17:39:39Z-
dc.date.issued2023-01-
dc.citation.volume52pt_BR
dc.citation.issue1pt_BR
dc.citation.spage32pt_BR
dc.citation.epage43pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.ijom.2022.09.004pt_BR
dc.identifier.issn1399-0020pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/80467-
dc.description.resumoOdontogenic keratocysts (OKC) are benign but aggressive lesions. As there is a lack of well randomized clinical studies assessing the effectiveness of the different treatment options for OKC, a network meta-analysis (NMA) was performed to identify the best treatment option with the lowest recurrence rate. An electronic search was performed following the PRISMA guidelines to identify all clinical studies comparing treatment options against enucleation alone. The outcome variable was recurrence. The predictor variables were treatments. The eight included treatments were: enucleation with peripheral ostectomy/curettage (E + PO/curettage); enucleation with cryotherapy (E + CRYO); enucleation with/without PO followed by modified Carnoy's solution (E ± PO+MCS); enucleation with PO and with topical 5-fluorouracil (E + PO+5FU); enucleation with/without PO followed by original Carnoy's solution (E ± PO+CS); marsupialization alone (MARS); marsupialization followed by secondary enucleation with/without PO (MARS+2°E ± PO); and resection. The odds ratio was used to estimate the recurrence rate. A frequentist NMA was performed using Stata software. A total of 2989 patients in 40 studies were included. Both direct pairwise meta-analysis and NMA showed that E + 5FU+PO was significantly superior to E ± PO+MCS. However, no statistically significant difference was found between E ± PO+CS vs E + 5FU+PO, E ± PO+MCS, and resection, respectively (all very low quality evidence). The three most effective treatments in reducing the recurrence rate were E + PO+ 5FU (98.1%; very low quality evidence), resection (83.5%; very low quality evidence), and E ± PO+CS (63.8%; moderate quality evidence). The findings from this study suggest that CS remains the most effective fixative agent after enucleation and PO until proven otherwise. Additionally, 5FU appears to be an effective method with promising results that needs further research. Finally, the efficacy of MCS remains controversial; further in vivo and in vitro studies are required to determine new protocols. As this NMA included retrospective studies, the results should be interpreted with great caution (level of evidence: type III).pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofInternational Journal of Oral and Maxillofacial Surgerypt_BR
dc.rightsAcesso Restritopt_BR
dc.subject5-fluorouracilpt_BR
dc.subjectCarnoy’s solutionpt_BR
dc.subjectCurettagept_BR
dc.subjectKeratocystic odontogenic tumorpt_BR
dc.subjectMarsupializationpt_BR
dc.subjectModified Carnoy’s solutionpt_BR
dc.subjectNetwork meta-analysispt_BR
dc.subjectOdontogenic cystspt_BR
dc.subjectOdontogenic keratocystpt_BR
dc.subjectOdontogenic tumorspt_BR
dc.subjectPeripheral ostectomypt_BR
dc.subjectSurgical decompressionpt_BR
dc.subject.otherFluorouracilpt_BR
dc.subject.otherCurettagept_BR
dc.subject.otherNetwork meta-analysispt_BR
dc.subject.otherOdontogenic cystspt_BR
dc.subject.otherOdontogenic tumorspt_BR
dc.subject.otherDecompression, surgicalpt_BR
dc.subject.otherRecurrencept_BR
dc.titleEffectiveness of different treatments for odontogenic keratocyst: a network meta-analysispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0901502722003794?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3649-9662pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8770-8009pt_BR
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