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http://hdl.handle.net/1843/81438| Type: | Artigo de Periódico |
| Title: | Galectin-3 and fibrosis intensity in Chronic Chagas Cardiomyopathy: a systematic review |
| Authors: | Ana Thereza Chaves Lages Ana Laura Grossi de Oliveira Nathalia Sernizon Guimarães Isabela Cristina Magalhães Cristiane Alves da Silva Menezes Manoel Otávio da Costa Rocha |
| Abstract: | Chronic Chagas Cardiomyopathy (CCC) is the most prevalent type of myocarditis and the main clinical form of the Chagas disease, which has peculiarities such as focal inflammation, structural derangement, hypertrophy, dilation, and intense reparative fibrosis. Many cellular compounds contribute to CCC development. Galectin-3 is a partaker in inflammation and contributes to myocardial fibrosis formation. Some studies showed the connection between Galectin-3 and fibrosis in Chagas disease but are still inconclusive on the guidance for the early implementation of pharmacological therapy. This systematic review evaluated Galectin-3 as a biomarker for fibrosis intensity in CCC. Two independent reviewers have searched five databases (PubMed, EMBASE, Cochrane Library, Scopus, and Lilacs), using the following search terms: galectin-3, biomarkers, fibrosis, Chagas cardiomyopathy, and Chagas disease. Overall, seven studies met the inclusion criteria and made up this review. There were four trials conducted through animal model experiments and three trials with humans. Experimental data in mice indicate an association between Galectin-3 expression and fibrosis in CCC (75% of studies). Data from human studies showed no direct connection between myocardial fibrosis and Galectin-3 expression (80% of studies). Thus, human findings do not provide significant evidence indicating that Galectin-3 is related to fibrosis formation in Chagas disease. Based on the analyzed studies, it is suggested that Galectin-3 might not be a good fibrosis marker in CCC. |
| Subject: | Galectina 3 Cardiomiopatia chagásica Doença de Chagas Fibrose |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAR - DEPARTAMENTO DE ANÁLISES CLÍNICAS E TOXICOLÓGICAS MED - DEPARTAMENTO DE CLÍNICA MÉDICA |
| Rights: | Acesso Aberto |
| metadata.dc.identifier.doi: | http://doi.org/10.1590/S1678-9946202264045 |
| URI: | http://hdl.handle.net/1843/81438 |
| Issue Date: | 2022 |
| metadata.dc.relation.ispartof: | Instituto de medicina tropical de São Paulo |
| Appears in Collections: | Artigo de Periódico |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Galectin-3 and fibrosis intensity in Chronic Chagas Cardiomyopathy a systematic review.pdf | 258.31 kB | Adobe PDF | View/Open |
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