1. Repositório Institucional da UFMG
  2. Publicações Científicas e Culturais
  3. Artigo de Periódico
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/81836
Registro completo de metadatos
Campo DCValorIdioma
dc.creatorEduardo Frois Temponipt_BR
dc.creatorPaulo Eduardo Alencar Souzapt_BR
dc.creatorGiovanna Ribeiro Soutopt_BR
dc.creatorLuísa Mourão Dias Magalhãespt_BR
dc.creatorWalderez Ornelas Dutrapt_BR
dc.creatorKenneth John Gollobpt_BR
dc.creatorTarcília Aparecida da Silvapt_BR
dc.creatorRodrigo Villamarim Soarespt_BR
dc.date.accessioned2025-04-24T22:07:00Z-
dc.date.available2025-04-24T22:07:00Z-
dc.date.issued2019-11-
dc.citation.volume10pt_BR
dc.citation.issue4pt_BR
dc.citation.spagee12472pt_BR
dc.citation.epagee12477pt_BR
dc.identifier.doihttps://doi.org/10.1111/jicd.12472pt_BR
dc.identifier.issn2041-1626pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/81836-
dc.description.resumoAim: To evaluate biological behavior of human peripheral mononuclear cells (PBMC) in contact with porous tantalum (PT) and Porphyromonas gingivalis (Pg). Methods: Pg was incubated for 8 hours. The groups formed were: PBMC (control), PBMC + PT, PBMC + Pg and PBMC + PT + Pg. Cell viability was evaluated using MTT assay. The morphology and adhesion of PBMC to PT was evaluated using scanning electron microscopy. Expression of interleukin (IL)-10, transforming growth factor (TGF)-β, matrix metallopeptidase (MMP)-9 and receptor activator of nuclear factor-κΒ ligand (RANKL) was determined by enzyme-linked immunosorbent assay. Results: MTT assay revealed that PT did not interfere in the mitochondrial activity of PBMC (P > .05). Scanning electron microscopy showed the adherence of PBMC to PT. IL-10 levels in PBMC + PT were similar to PBMC and lower than PBMC + Pg. TGF-β levels in PBMC + PT were higher than PBMC and PBMC + Pg. MMP-9 levels in PBMC + PT were similar to PBMC and lower than PBMC + Pg and PBMC + PT + Pg. RANKL levels in PBMC + PT were lower than in PBMC. Conclusion: PT did not affect PBMC viability, allowed cell adhesion, reduced expression of RANKL and enhanced TGF-β in comparison with the control group.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Geraispt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofJournal of investigative and clinical dentistrypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectPorphyromonas gingivalispt_BR
dc.subjectCytokinespt_BR
dc.subjectHuman peripheral mononuclear cellspt_BR
dc.subjectImplantologypt_BR
dc.subjectPorous tantalumpt_BR
dc.subject.otherCytokinespt_BR
dc.subject.otherPorphyromonas gingivalispt_BR
dc.subject.otherLeukocytes, mononuclearpt_BR
dc.subject.otherBehaviorpt_BR
dc.subject.otherBiologypt_BR
dc.subject.otherCell adhesionpt_BR
dc.subject.otherTransforming growth factor betapt_BR
dc.subject.otherRANK ligandpt_BR
dc.subject.otherTantalumpt_BR
dc.titleEffect of porous tantalum on the biological response of human peripheral mononuclear cells exposed to Porphyromonas gingivalispt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jicd.12472pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0612-7275pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5166-1982pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-3617-8794pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9957-3295pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7586-9996pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4184-3867pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9623-7835pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7698-7532pt_BR
Aparece en las colecciones:Artigo de Periódico

archivos asociados a este elemento:
no existem archivos asociados a este elemento.
Mostrar registro simple del elemento Visualizar estadísticas


Los elementos en el repositorio están protegidos por copyright, con todos los derechos reservados, salvo cuando es indicado lo contrario.