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  3. Artigo de Periódico
Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/82148
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Campo DCValorIdioma
dc.creatorVasantha Dharapt_BR
dc.creatorThilak P.S. Gopinathpt_BR
dc.creatorSameep S. Shettypt_BR
dc.creatorJosé Alcides Almeida de Arrudapt_BR
dc.creatorTarcília Aparecida da Silvapt_BR
dc.creatorRemo Castro Russopt_BR
dc.creatorNeetha J. Shettypt_BR
dc.creatorManasa Pidaparthipt_BR
dc.creatorBarbara Wollenbergpt_BR
dc.creatorVishal U.S. Raopt_BR
dc.date.accessioned2025-05-08T19:27:44Z-
dc.date.available2025-05-08T19:27:44Z-
dc.date.issued2023-01-
dc.citation.volume69pt_BR
dc.citation.issue1pt_BR
dc.citation.spage101353pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.disamonth.2022.101353pt_BR
dc.identifier.issn1557-8194pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/82148-
dc.description.resumoIn recent decades, understanding tumorigenesis and the complex interaction between the host and the immune system has been the pillar for significant advances in anticancer therapy. Conventional anticancer therapy (e.g., cut, burn, and cytotoxic drugs) involves multiple targeting of tumor cells. However, the tumor tissue microenvironment can present a dysregulated, stimulating, or subverted immune response which, in turn, reveals pro-tumor activities favoring tumor expansion and progression. Recently, new potential targets have been identified based on immunomodulatory therapies, which are crafted to re-establish the host anti-tumoral immune response. Clinicians should fully understand the intricate interactions between carcinogens, the tumor milieu, the immune system, and traditional anticancer therapies in order to progress and to overcome the refractory/recurrent challenges and morbidity of the disease. Thus, in this article, we highlight the complex milieu of the oral cancer immune response, pointing out potential therapeutic immunotargets for oral squamous cell carcinomas. The impact of traditional anticancer therapy on the immune system is also outlined.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofDisease-a-Monthpt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectImmune systempt_BR
dc.subjectImmunotherapypt_BR
dc.subjectInflammationpt_BR
dc.subjectOral oncologypt_BR
dc.subjectOral squamous cell carcinomapt_BR
dc.subjectTumor microenvironmentpt_BR
dc.subject.otherImmune systempt_BR
dc.subject.otherImmunosuppression therapypt_BR
dc.subject.otherInflammationpt_BR
dc.subject.otherSquamous cell carcinoma of head and neckpt_BR
dc.subject.otherTumor microenvironmentpt_BR
dc.titleDecoding the influence of the immune system and immunotherapy targets on carcinomas: a hidden prism in oral cancer therapypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0011502922000372?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8841-6235pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4312-8322pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7625-7289pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8729-9348pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6599-3950pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9623-7835pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1715-3834pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6167-5114pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3062-459Xpt_BR
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