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http://hdl.handle.net/1843/82148| Type: | Artigo de Periódico |
| Title: | Decoding the influence of the immune system and immunotherapy targets on carcinomas: a hidden prism in oral cancer therapy |
| Authors: | Vasantha Dhara Thilak P.S. Gopinath Sameep S. Shetty José Alcides Almeida de Arruda Tarcília Aparecida da Silva Remo Castro Russo Neetha J. Shetty Manasa Pidaparthi Barbara Wollenberg Vishal U.S. Rao |
| Abstract: | In recent decades, understanding tumorigenesis and the complex interaction between the host and the immune system has been the pillar for significant advances in anticancer therapy. Conventional anticancer therapy (e.g., cut, burn, and cytotoxic drugs) involves multiple targeting of tumor cells. However, the tumor tissue microenvironment can present a dysregulated, stimulating, or subverted immune response which, in turn, reveals pro-tumor activities favoring tumor expansion and progression. Recently, new potential targets have been identified based on immunomodulatory therapies, which are crafted to re-establish the host anti-tumoral immune response. Clinicians should fully understand the intricate interactions between carcinogens, the tumor milieu, the immune system, and traditional anticancer therapies in order to progress and to overcome the refractory/recurrent challenges and morbidity of the disease. Thus, in this article, we highlight the complex milieu of the oral cancer immune response, pointing out potential therapeutic immunotargets for oral squamous cell carcinomas. The impact of traditional anticancer therapy on the immune system is also outlined. |
| Subject: | Immune system Immunosuppression therapy Inflammation Squamous cell carcinoma of head and neck Tumor microenvironment |
| language: | eng |
| metadata.dc.publisher.country: | Brasil |
| Publisher: | Universidade Federal de Minas Gerais |
| Publisher Initials: | UFMG |
| metadata.dc.publisher.department: | FAO - DEPARTAMENTO DE CLÍNICA ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA |
| Rights: | Acesso Restrito |
| metadata.dc.identifier.doi: | https://doi.org/10.1016/j.disamonth.2022.101353 |
| URI: | http://hdl.handle.net/1843/82148 |
| Issue Date: | Jan-2023 |
| metadata.dc.url.externa: | https://www.sciencedirect.com/science/article/pii/S0011502922000372?via%3Dihub |
| metadata.dc.relation.ispartof: | Disease-a-Month |
| Appears in Collections: | Artigo de Periódico |
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