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http://hdl.handle.net/1843/82315| Tipo: | Artigo de Periódico |
| Título: | The participation of tumor residing pericytes in oral squamous cell carcinoma |
| Autor(es): | Isabella Bittencourt do Valle Gabriel da Silva Andréia Machado Leopoldino Soraia Macari Alexander Birbrair Sandra Ventorin von Zeidler Ivana Márcia Alves Diniz Tarcília Aparecida da Silva Sicília Rezende Oliveira Janine Mayra da Silva Gabriela Tonini Peterle Anna Clara Gregório Có Sebastião Silvério Sousa-Neto Elismauro Francisco Mendonça José Alcides Almeida de Arruda Natália Aparecida Gomes |
| Resumen: | Pericytes are perivascular cells related to vessel structure and angiogenesis that can interact with neoplastic cells, interfering with cancer progression and outcomes. This study focused on the characterization of pericytes in oral squamous cell carcinoma (OSCC) using clinical samples and a transgenic mouse model of oral carcinogenesis. Nestin-/NG2+ (type-1) and nestin+/NG2+ (type-2) pericytes were analyzed by direct fluorescence after induction of oral carcinogenesis (4-nitroquinoline-1-oxide). Gene expression of neuron glial antigen-2 (NG2), platelet-derived growth factor receptor beta (PDGFR-β), and cluster of differentiation 31 (CD31) was examined in human OSCC tissues. The protein expression of von Willebrand factor and NG2 was assessed in oral leukoplakia (i.e., oral potentially malignant disorders) and OSCC samples. Additionally, clinicopathological aspects and survival data were correlated and validated by bioinformatics using The Cancer Genome Atlas (TCGA). Induction of carcinogenesis in mice produced an increase in both NG2+ pericyte subsets. In human OSCC, advanced-stage tumors showed a significant reduction in CD31 mRNA and von Willebrand factor-positive vessels. Low PDGFR-β expression was related to a shorter disease-free survival time, while NG2 mRNA overexpression was associated with a reduction in overall survival, consistent with the TCGA data. Herein, oral carcinogenesis resulted in an increase in NG2+ pericytes, which negatively affected survival outcomes. |
| Asunto: | Neoplasms Pericytes Mouth neoplasms Carcinogenesis Gene expression Proteins Survival RNA, messenger Platelet endothelial cell adhesion molecule-1 Squamous cell carcinoma of head and neck Leukoplakia, oral Evaluation study Receptor, platelet-derived growth factor beta Nestin Von Willebrand factor |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Institución: | UFMG |
| Departamento: | FAO - DEPARTAMENTO DE CLÍNICA FAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA |
| Tipo de acceso: | Acesso Aberto |
| Identificador DOI: | https://doi.org/10.1038/s41598-023-32528-1 |
| URI: | http://hdl.handle.net/1843/82315 |
| Fecha del documento: | 2023 |
| metadata.dc.url.externa: | https://www.nature.com/articles/s41598-023-32528-1 |
| metadata.dc.relation.ispartof: | Scientific reports |
| Aparece en las colecciones: | Artigo de Periódico |
archivos asociados a este elemento:
| archivo | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| The participation of tumor residing pericytes in oral squamous cell carcinoma.pdf | 11.97 MB | Adobe PDF | Visualizar/Abrir |
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