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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/82349
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Campo DCValorIdioma
dc.creatorLady Katerine Serrano Mujicapt_BR
dc.creatorAntônio Carlos Shimanopt_BR
dc.creatorAlfredo Quites Antoniazzipt_BR
dc.creatorMelissa Orlandin Premaorpt_BR
dc.creatorFabio Vasconcellos Comimpt_BR
dc.creatorCarolina dos Santos Amaralpt_BR
dc.creatorFernanda Soldatelli Valentept_BR
dc.creatorLigia Gomes Miyazatopt_BR
dc.creatorSoraia Macaript_BR
dc.creatorTarcília Aparecida da Silvapt_BR
dc.creatorBreno Rocha Barrionipt_BR
dc.creatorBruna Leonel Carlospt_BR
dc.creatorGuilherme Jafroni Alves Silvapt_BR
dc.date.accessioned2025-05-19T21:49:33Z-
dc.date.available2025-05-19T21:49:33Z-
dc.date.issued2023-12-
dc.citation.volume19pt_BR
dc.citation.spage1pt_BR
dc.citation.epage10pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.bonr.2023.101710pt_BR
dc.identifier.issn2352-1872pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/82349-
dc.description.resumoBackground: Whether polycystic ovary syndrome (PCOS) affects bone health during a woman's lifespan remains controversial. An androgenized rodent model replicated many metabolic and reproductive features of women with PCOS, and we aimed to use it to investigate the impact of androgens on microarchitecture (by micro-CT), bone mechanical strength, bone formation and resorption markers in rats with intact ovaries (SHAM) who underwent oophorectomy. Methods: Wistar rats (Rattus norvegicus albinus) were employed for the experiments in this study. The protocol of androgenization consisted of the application of 1.25 mg s.c. testosterone propionate beteween days 2–5 of life, while the controls received the same amount of corn oil s.c. as previously established. Androgenized SHAM rats exhibited chronic anovulation identified by vaginal cytology and a reduction in the proportion of corpus luteum in the ovary in comparison to control SHAM rats. The realization of the ovariectomy or SHAM procedure occurred on Day 100 of life. All groups (n = 8) were followed-up for 180 days to address the study endpoints. Results: Micro-CT from androgenized female rats (SHAM) showed a divergence between the trabecular and cortical bone profiles. Compared to SHAM controls, these rats had an increase in trabecular bone mass with a diminution in bone resorption C-terminal telopeptide of type 1 collagen (CTX) (p < 0.05), a concomitant decrease in cortical area and thickness in the femur, and a reduction in the strength of the femur on the mechanical test (p < 0.01). Conclusions: Our results suggest that a reduction in the cortical thickness and cortical area observed in PCOS model rats was associated with a reduced strength of the femur, despite increased trabecular formation. Ovariectomy in the androgenized OVX group limited the progression rate of cortical bone loss, resulting in bone resistance and cortical thickness comparable to those observed in the control OVX group.pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORApt_BR
dc.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofBone reportspt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectPolycystic ovary syndromept_BR
dc.subjectBonept_BR
dc.subjectAnimal models of PCOSpt_BR
dc.subjectmicroCTpt_BR
dc.subjectMechanical testpt_BR
dc.subject.otherBone and bonespt_BR
dc.subject.otherPolycystic ovary syndromept_BR
dc.subject.otherMechanical testspt_BR
dc.subject.otherBone resorptionpt_BR
dc.subject.otherFemurpt_BR
dc.subject.otherCollagen type Ipt_BR
dc.subject.otherOvariectomypt_BR
dc.titleBone strength is reduced in a neonatal androgenized rat modelpt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S235218722300058X#ks0005pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8009-1480pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3119-2362pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4866-5944pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0770-9202pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-2726-233Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5932-0522pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9317-4605pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8556-5083pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7643-6589pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-9623-7835pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8681-6451pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6726-4217pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7621-1726pt_BR
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