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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/83189
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Campo DCValorIdioma
dc.creatorMarina Gonçalves Dinizpt_BR
dc.creatorCarolina Cavalieri Gomespt_BR
dc.creatorSílvia Ferreira de Sousapt_BR
dc.creatorGuilherme Machado Xavierpt_BR
dc.creatorRicardo Santiago Gomezpt_BR
dc.date.accessioned2025-06-26T21:06:03Z-
dc.date.available2025-06-26T21:06:03Z-
dc.date.issued2017-09-
dc.citation.volume72pt_BR
dc.citation.spage165pt_BR
dc.citation.epage173pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.oraloncology.2017.07.021pt_BR
dc.identifier.issn1879-0593pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/83189-
dc.description.resumoThe first step towards the prevention of cancer is to develop an in-depth understanding of tumourigenesis and the molecular basis of malignant transformation. What drives tumour initiation? Why do most benign tumours fail to metastasize? Oncogenic mutations, previously considered to be the hallmark drivers of cancers, are reported in benign cysts and tumours, including those that have an odontogenic origin. Despite the presence of such alterations, the vast majority of odontogenic lesions are benign and never progress to the stage of malignant transformation. As these lesions are likely to develop due to developmental defects, it is possible that they harbour quiet genomes. Now the question arises - do they result from DNA replication errors? Specific candidate genes have been sequenced in odontogenic lesions, revealing recurrent BRAF mutation in the case of ameloblastoma, KRAS mutation in adenomatoid odontogenic tumours, PTCH1 mutation in odontogenic keratocysts, and CTNNB1 (Beta-catenin) mutation in calcifying odontogenic cysts. Studies on these benign and rare entities might reveal important information about the tumorigenic process and the mechanisms that hinder/halt neoplastic progression. This is because the role of relatively common oncogenic mutations seems to be context dependent. In this review, each mutation signature of the odontogenic lesion and the affected signalling pathways are discussed in the context of tooth development and tumorigenesis. Furthermore, behavioural differences between different types of odontogenic lesions are explored and discussed based on the molecular alteration described. This review also includes the employment of molecular results for guiding therapeutic approaches towards odontogenic lesions.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE MORFOLOGIApt_BR
dc.publisher.departmentICB - DEPARTAMENTO DE PATOLOGIApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofOral Oncologypt_BR
dc.rightsAcesso Restritopt_BR
dc.subjectBenign tumourspt_BR
dc.subjectOdontogenic cystspt_BR
dc.subjectOdontogenic tumorspt_BR
dc.subjectGeneticspt_BR
dc.subjectOncogenic signallingpt_BR
dc.subjectOncogenic mutationspt_BR
dc.subjectOral cancerpt_BR
dc.subjectTumorigenesispt_BR
dc.subject.otherGeneticspt_BR
dc.subject.otherNeoplasmspt_BR
dc.subject.otherOdontogenic cystspt_BR
dc.subject.otherOdontogenic tumorspt_BR
dc.subject.otherMouth neoplasmspt_BR
dc.subject.otherCarcinogenesispt_BR
dc.subject.otherSignal transductionpt_BR
dc.subject.otherMutationpt_BR
dc.subject.otherTherapeuticspt_BR
dc.titleOncogenic signalling pathways in benign odontogenic cysts and tumourspt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S1368837517302129?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4212-1172pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1580-4995pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-7820-4749pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8770-8009pt_BR
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