Please use this identifier to cite or link to this item: http://hdl.handle.net/1843/83189
Type: Artigo de Periódico
Title: Oncogenic signalling pathways in benign odontogenic cysts and tumours
Authors: Marina Gonçalves Diniz
Carolina Cavalieri Gomes
Sílvia Ferreira de Sousa
Guilherme Machado Xavier
Ricardo Santiago Gomez
Abstract: The first step towards the prevention of cancer is to develop an in-depth understanding of tumourigenesis and the molecular basis of malignant transformation. What drives tumour initiation? Why do most benign tumours fail to metastasize? Oncogenic mutations, previously considered to be the hallmark drivers of cancers, are reported in benign cysts and tumours, including those that have an odontogenic origin. Despite the presence of such alterations, the vast majority of odontogenic lesions are benign and never progress to the stage of malignant transformation. As these lesions are likely to develop due to developmental defects, it is possible that they harbour quiet genomes. Now the question arises - do they result from DNA replication errors? Specific candidate genes have been sequenced in odontogenic lesions, revealing recurrent BRAF mutation in the case of ameloblastoma, KRAS mutation in adenomatoid odontogenic tumours, PTCH1 mutation in odontogenic keratocysts, and CTNNB1 (Beta-catenin) mutation in calcifying odontogenic cysts. Studies on these benign and rare entities might reveal important information about the tumorigenic process and the mechanisms that hinder/halt neoplastic progression. This is because the role of relatively common oncogenic mutations seems to be context dependent. In this review, each mutation signature of the odontogenic lesion and the affected signalling pathways are discussed in the context of tooth development and tumorigenesis. Furthermore, behavioural differences between different types of odontogenic lesions are explored and discussed based on the molecular alteration described. This review also includes the employment of molecular results for guiding therapeutic approaches towards odontogenic lesions.
Subject: Genetics
Neoplasms
Odontogenic cysts
Odontogenic tumors
Mouth neoplasms
Carcinogenesis
Signal transduction
Mutation
Therapeutics
language: eng
metadata.dc.publisher.country: Brasil
Publisher: Universidade Federal de Minas Gerais
Publisher Initials: UFMG
metadata.dc.publisher.department: FAO - DEPARTAMENTO DE CLÍNICA
ICB - DEPARTAMENTO DE MORFOLOGIA
ICB - DEPARTAMENTO DE PATOLOGIA
Rights: Acesso Restrito
metadata.dc.identifier.doi: https://doi.org/10.1016/j.oraloncology.2017.07.021
URI: http://hdl.handle.net/1843/83189
Issue Date: Sep-2017
metadata.dc.url.externa: https://www.sciencedirect.com/science/article/pii/S1368837517302129?via%3Dihub
metadata.dc.relation.ispartof: Oral Oncology
Appears in Collections:Artigo de Periódico

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