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http://hdl.handle.net/1843/83552| Tipo: | Artigo de Periódico |
| Título: | Liposomal amphotericin b for treatment of leishmaniasis: from the identification of critical physicochemical attributes to the design of effective topical and oral formulations |
| Autor(es): | Frédéric Jean Georges Frézard Marta Marques Gontijo de Aguiar Lucas Antonio Miranda Ferreira Guilherme Santos Ramos Thais Tunes Santos Gabriel Silva Marques Borges Virgínia Mendes Russo Vallejos Helane Lúcia Oliveira de Morais |
| Resumo: | The liposomal amphotericin B (AmB) formulation, AmBisome®, still represents the best therapeutic option for cutaneous and visceral leishmaniasis. However, its clinical efficacy depends on the patient’s immunological status, the clinical manifestation and the endemic region. Moreover, the need for parenteral administration, its side effects and high cost significantly limit its use in developing countries. This review reports the progress achieved thus far toward the understanding of the mechanism responsible for the reduced toxicity of liposomal AmB formulations and the factors that influence their efficacy against leishmaniasis. It also presents the recent advances in the development of more effective liposomal AmB formulations, including topical and oral liposome formulations. The critical role of the AmB aggregation state and release rate in the reduction of drug toxicity and in the drug efficacy by non-invasive routes is emphasized. This paper is expected to guide future research and development of innovative liposomal formulations of AmB. |
| Assunto: | Lipossomos Anfotericina B Anfotericina B Leishmaniose Vias de administração de medicamentos |
| Idioma: | eng |
| País: | Brasil |
| Editor: | Universidade Federal de Minas Gerais |
| Sigla da Instituição: | UFMG |
| Departamento: | FAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS ICB - DEPARTAMENTO DE FISIOLOGIA E BIOFÍSICA |
| Tipo de Acesso: | Acesso Aberto |
| Identificador DOI: | 10.3390/pharmaceutics15010099 |
| URI: | http://hdl.handle.net/1843/83552 |
| Data do documento: | Dez-2023 |
| metadata.dc.url.externa: | https://www.mdpi.com/1999-4923/15/1/99 |
| metadata.dc.relation.ispartof: | Pharmaceutics |
| Aparece nas coleções: | Artigo de Periódico |
Arquivos associados a este item:
| Arquivo | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Liposomal Amphotericin B for Treatment of Leishmaniasis.pdf | 2.98 MB | Adobe PDF | Visualizar/Abrir |
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