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Use este identificador para citar o ir al link de este elemento: http://hdl.handle.net/1843/83978
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Campo DCValorIdioma
dc.creatorMillena Christie Ferreira Avelarpt_BR
dc.creatorClésia Cristina Nascentespt_BR
dc.creatorRicardo Mathias Orlandopt_BR
dc.date.accessioned2025-08-04T17:18:41Z-
dc.date.available2025-08-04T17:18:41Z-
dc.date.issued2021-
dc.citation.volume224pt_BR
dc.citation.spage121887pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.talanta.2020.121887pt_BR
dc.identifier.issn00399140pt_BR
dc.identifier.urihttp://hdl.handle.net/1843/83978-
dc.description.resumoIn this work, for the first time, chromatographic paper was used for a multiphase extraction assisted by an electric field (MPEF) and directly coupled to paper spray mass spectrometry (PS-MS). Using this approach, five tricyclic antidepressants (TCAs) were determined in oral fluid. Firstly, the MPEF conditions were optimized using liquid chromatography-mass spectrometry (LC-MS/MS). The effects of the chromatographic paper and the types of electrolyte used in the acceptor phase, the organic solvent type and the amount used in the donor phase, the extraction time, and the applied electric potential were all investigated. After optimization, the analytes were extracted from the donor solution (sample and acetonitrile 1:1 (v/v)) over a period of 10 min at 300 V, crossing the free liquid membrane (1-octanol) and reaching the acceptor phase (chromatographic paper wetted with 400 mmol L−1 acetic acid). The method using LC-MS/MS was validated, demonstrating a linear range from 2 to 12 ng mL−1, with detection and quantification limits of 0.13–0.25 and 0.44–0.84 ng mL−1, respectively, an intraday precision of less than 20%, and no matrix effect observed. The optimized MPEF conditions were then applied to determine TCAs by PS-MS and for this analysis cyclobenzaprine was used as an internal standard. The easy, fast and direct approach of coupling MPEF with PS-MS analysis, as well as the pre-concentration and the low standard deviation of replicates (less than 20%), demonstrates that this method can be useful for screening in clinical and toxicological analysis.pt_BR
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpt_BR
dc.description.sponsorshipINCT – Instituto nacional de ciência e tecnologia (Antigo Instituto do Milênio)pt_BR
dc.format.mimetypepdfpt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Minas Geraispt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentICX - DEPARTAMENTO DE QUÍMICApt_BR
dc.publisher.initialsUFMGpt_BR
dc.relation.ispartofTalantapt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectTricyclic antidepressantspt_BR
dc.subjectOral fluidpt_BR
dc.subjectMultiphase electroextractionpt_BR
dc.subjectFree liquid membranept_BR
dc.subjectPaper spray mass spectrometrypt_BR
dc.subject.otherAntidepressivospt_BR
dc.subject.otherEspectrometria de massapt_BR
dc.subject.otherCromatografia líquidapt_BR
dc.subject.otherSolventes orgânicospt_BR
dc.titleElectric field-assisted multiphase extraction to increase selectivity and sensitivity in liquid chromatography-mass spectrometry and paper spray mass spectrometrypt_BR
dc.typeArtigo de Periódicopt_BR
dc.url.externahttps://www.sciencedirect.com/science/article/pii/S0039914020311784?via%3Dihubpt_BR
dc.identifier.orcidhttps://orcid.org/0009-0003-9409-8431pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8514-442Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3862-1211pt_BR
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