Análise da toxicidade dos antidepressivos tricíclicos (ADTS) e plano de intervenção

Abstract

The municipality of Jaboticatubas has a territorial extension of 1.114KM2 . Is located in the Metropolitan Region of Belo Horizonte and is located in the Southeast region, in the State of Minas Gerais, in the Metallurgical, microregion calcareous Sete Lagoas. During the meeting of family health team in the municipality of Jaboticatubas, was discussed the major use of antidepressant medication, especially the class of tricyclic antidepressants (ADTS), and it was found that the use of indiscriminate and packaging incorrectly this medication leading to several cases of poisoning. The tricyclic antidepressants are a class of drugs used to treat symptoms of depression and other depressive syndromes. They are recognized as being the most effective in depressive episodes serious, although acclaimed by effectiveness are drugs recognized, also, by a low therapeutic index in relation to other classes of antidepressants. The present study aimed to elaborate a plan of action that will enable citizens' awareness of the risks of inappropriate use of tricyclic antidepressants and about the importance of appropriate packaging. Methodologically, supported in an integrative review using studies on the toxicity of tricyclic antidepressants by analyzing its main adverse effects and toxic effects for the creation, therefore, the plan of action. To this end, research in databases were performed and defined thereafter , articles that met the inclusion criteria of the proposed methodology as well as the interest of certain variables were collected . The survey resulted in a sample composed of 16 articles selected from a population of 111 scientific papers . The results showed that the inappropriate use of the drug may trigger autointoxication leading to cardiac abnormalities and central nervous system. The main circumstances involved in the poisonings were suicide , self-medication and drug use associated with alcohol . From the review carried out can be seen that it is a class of drugs with adverse and toxic effects that may impair the quality of life . Some measures are suggested to reduce these occurrences of poisoning , such as the best dosage adjustment of patients on therapy, the combination of cognitive- behavioral therapies to reduce the incidence of suicide attempts , reduce the rate of childhood accidents due to carelessness and lack of knowledge of medicines and educational campaigns about the toxicity of drugs .