Ação do BDNF na via dopaminérgica mesolímbica e seu papel na aquisição da memória em modelos de animais sob estresse

Abstract

Brain-derived neurotrophic factor (BDNF) plays a key role in neuronal plasticity and memory. It has been described that BDNF mediates important processes, such as learning and memory, which make it a potential mediator of neurobiological effects of life experiences. Studies have pointed to a change in hippocampal BDNF level related to stress. Wherein acute stress factors reduce long-term potentiation (LTP) in the dorsal hippocampus, and selectively increase monoamine levels and LTP in the sub ventral region. These data suggest that hippocampus plays a dual role in stress response, with dorsal portion subjected to adaptive plasticity, perhaps to facilitate escape or avoid stressor, and ventral portion involved in affective aspects of experience. Studies have shown that increasing BDNF promotes dopaminergic pathway-enhancing learning memory behavior in the associative phenomenon, although a recent study showed that chronic generalized increase in BDNF expression in the central nervous system has led to a number of learning disabilities and loss in short term memory. A study to assess the level of BDNF in the ventral hippocampal region and the levels of its precursor pro-BDNF, can elucidate some shortcomings in memory consolidation process. Objective: to correlate the level of BDNF with explicit memory in order to verify that the stress of immobilization influence this relationship. Methodology: Bibliographic survey in CAPES portal of scientific papers related to the level of BDNF in relation to explicit memory and stress by immobilization.