As proteínas derivadas da matriz de esmalte na terapia periodontal

Abstract

Lately, innovations on periodontal regenerative therapy have significantly improved the results of treatments, but a reflection is needed to lead us make the correct decision for each case. Many growth factors have been used in the last decades, with different rates of success. Studies have shown that many of these growth factors can really promote periodontal regeneration. Recently, enamel matrix derivate (Emdogain®) has appeared as an alternative approach for periodontal regeneration, creating an extracellular matrix that allows recolonization of root surfaces by cementoblasts-like cells, inducing formation of new acellular cementum and inhibiting epithelium migration. Histological studies have shown divergent results, but it is proved that Emdogain® significantly improves periodontal attachment levels and reduces probing pocket depth when compared with open-flap debridement. Although studies are promising, the clinical use of Emdogain® is still limited by technical specificity and high charges.