Efetividade do tratamento antirretroviral em 48 semanas de acompanhamento em serviço de referência para pessoas vivendo com HIV/AIDS, Belo Horizonte, Minas Gerais 2010 a 2013

Abstract

Introduction: The epidemic of the human immunodeficiency virus HIV is a major public health problem worldwide and a challenge to be overcome. The diagnosis of HIV is delayed, which generates negative implications for the person as an individual and society. The introduction of Highly Active Antiretroviral Therapy (HAART) turned a highly lethal disease into a chronic process, it made the clinical management easier and significantly increased the survival rate and quality of life of people living with HIV/AIDS (PLWHA). There are few Brazilian data on the effectiveness of the first ARV regimen, which justifies the development of this study. Objectives: To describe the clinical and epidemiological features of the studied population, their immunological and virological response to treatment; to analyze the effectiveness of the first antiretroviral regimen within 48 weeks of initiation of HAART. Methods: All patients undergoing treatment at CTR-DIP HC-UFMG / PBH service that started HAART for the treatment of HIV infection between October 2010 and January 2013, that had 18 years of age, both sexes, were invited to participate the study. The project was approved by paragraph COEP-UFMG. ETIC 0251.0.203.000-11. Results: 191 patients were included with a male predominance, neither white or black, median age 37,5 years old and with 8 to 11 years of study. As to serology for viral hepatitis are available, 2.4% were seropositive for HBsAg and 4.6% for hepatitis C. The average initial CD4 cell count was low (275 cells / mL) and 11.7% had initial VL larger than 100,000 copies / mL. The most commonly used ARV regimen AZT / 3TC and EFV (49.7%). PI-containing regimens accounted for only 17.7%. The rate of effectiveness measured through VL <50 copies / mL was 91,4% in the studied time frame. Discussion: The socio-demographic characteristics of the study population were consistent with those described by MH and prescribed ARV followed the recommendations. Perceives late onset of ARV however with good therapeutic response. Conclusion: Despite the late start of HAART and the immune virologic responses were higher estimated ace showing greater effectiveness in relation to other studies.