Avaliação dos mecanismos de intolerância ao exercício em indivíduos com diferentes disfunções

Abstract

Functional capacity depends on the integrity and regulation of respiratory, cardiovascular and neuromuscular systems during physical exercise. The identification of the possible causes of exercise intolerance in patients with different dysfunctions may help in the development of rehabilitation strategies according to the limitations of these patients. The aim of this study was to evaluate the cardiorespiratory and metabolic parameters that limit functional capacity in patients with chronic heart failure (HF), chronic obstructive pulmonary disease (COPD), obesity (OB) and Parkinson's disease (PARK) and compare them with healthy individuals (CTR). Subjects with a clinical diagnosis of COPD (n = 10), HF (n = 11), OB (n = 11) and PARK (n = 11) performed a maximal cardiopulmonary exercise test under ramp protocol. The test was made with continuous analysis of expired gases, electrocardiographic monitoring, blood pressure measurement and peripheral oxygen saturation. A control group (CTR) with similar anthropometric characteristics was also stablished. The outcome variables were: peak oxygen consumption (VO2peak), oxygen pulse (VO2/HR), ventilatory equivalent of carbon dioxide (VE/VCO2) and double-product (DP). Data analysis was performed via one way analysis of variance (Anova) and multiple comparisons via Dunnett´s test. The results showed that individuals with HF and COPD had lower values of VO2peak and DP than the CTR group. The OB and PARK groups did not differ from the CTR.