Associação entre fadiga e desfechos de estrutura e função, atividade e participação em pessoas com doença de parkinson: uma revisão sistemática

Abstract

Aim: to investigate whether there is a relationship between fatigue and the outcomes of the three major domains of the International Classification of Functioning, Disability and Health (ICF) in people with Parkinson's disease (PD). The clinical question was: in PD population, does the fatigue relate to: 1) body structure and function, 2) activity and 3) participation? Methods: a systematic review of observational, analytical, non-analytical (cross-sectional) and experimental studies in humans (clinical trials) was performed. The study included participants with PD of all ages, gender or ethnicity. The outcomes were fatigue and other measures of body structure and function, activity and participation. Results: from the 60 studies that composed the sample, only the papers that measured the relationship between fatigue and gait (n = 3) were discussed at this review phase. Fatigue correlated with stride length, gait velocity, acceleration and gait capability, however, this symptom was not a predictor of gait in people with PD. In contrast, these spatio-temporal gait parameters are predictors of fatigue in people with PD. Conclusion: evidence on the relationship between fatigue and gait in PD is limited because of the small number of studies available. Nevertheless, this study showed that: 1) fatigue is a factor of small importance within the complexity of behaviors that determine gait in people with PD and that 2) the gait limitations in people with PD interfere with fatigue, suggesting the treatment of gait disturbance when fatigue is present in this population