Parâmetros bioquímicos, hemostáticos e moleculares em mulheres com "Diabetes mellitus" tipo 2 e diferentes graus de acometimento de carótida

Abstract

Risk for cardiovascular disease is five-fold higher in type 2 diabetes women than in women without diabetes. Increased plasma levels of hemostatic markers precede the development of type 2 diabetes and are associated with macrovascular disease. The aim of this study was to evaluate the biochemical, hemostatic and genetic5h changes in type 2 diabetes women with different carotid intima-media thickness assessed by doppler. Sixty four type 2 diabetes women classified into the following subgroups according to the carotid intima-media thickness were studied: 25 with normal result (<1mm), 15 intermediate (>1mm and without plaque) and 24 with plaque (stenosis lower than 50%). Influence of medication use was evaluated as a covariant among patients. The results of this study show that a single assessment of the lipid profile in type 2 diabetes women, after clinical and pharmacological intervention, do not allow speculation about the macrovascular disease progression. However, type 2 diabetes women with macrovascular disease present increased plasma levels of D-dimer, fibrinogen and factor VIII. Elevated PAI-1 levels in type 2 diabetes women are not associated with macrovascular progression; as well as MTHFR and glycoprotein IIIa polymorphism are not associated with type 2 diabetes. The results taken together, except fibrinogen, D-dimer and factor VIII, suggest that the worsening of this disease still in an earlier stage is not associated to the other laboratory parameters assessed in type 2 diabetes women in the conditions of the present study.