EFEITOS DA CLINDAMICINA E GENTAMICINA SOBRE AMOSTRAS ISOLADAS DE INFECÇÕES ODONTOGÊNICAS GRAVES: ESTUDO PILOTO

Abstract

Severe dental infections are a challenge to treatment by oral and maxillofacial surgeons, usually requiring surgical intervention and administration of intravenous antibiotics. The combination of clindamycin and gentamicin, has shown satisfactory results over the years. This study analyzed in vitro the type of effect caused by gentamicin and clindamycin on the strains isolated from severe dental infections. Twenty bacterial samples were used, 13 Streptococcus from Viridans group and 7 obligate anaerobes. These samples were inoculated in culture media containing clindamycin and gentamicin, singly and in combination. Utilizing the clindamycin in different concentrations and kept gentamicin 3 g/mL throughout the study. Streptococcus from Viridans group were kept for 24 hours in microaerophilic and anaerobic were kept in anaerobic jar for 48 hours both under a 37 ° C temperature. After the incubation period, the reading of the results was performed. Samples of Streptococcus Viridans group showed resistance to both drugs and combination there of, except for one, which was sensitive to gentamicin. Anaerobes showed mixed results, ranging from sensitivity or extreme resistance to variable effects and synergism by adding between drugs. It can be concluded that there is no synergistic effect of potentiation between gentamicin and clindamycin and, according to the spectrum of action of each drug, this combination can enhance hospital treatment of severe dental infections. New studies, however, are required to check whether the variable effects observed in this study may interfere with clinical outcomes.