Síntese, caracterização e estudo da atividade biológica de complexos dos elementos pnictogênicos Sb(III) e Bi(III) com ligantes ditiois multifuncionais

Abstract

This present work discusses the synthesis and characterization ofmultifunctional di(tri)thiols ligands and their complexes with the pnictogenics elements Sb(III) and Bi(III). In addition, it is reported a brief biological study, especially antibacterial, exhibited by the complexes obtained. Chapter 1 contains a collection of short texts which describe theorganosulfured compounds, especially thiols, and compounds of antimony and bismuth and their medicinal properties, besides the epidemiological problems of the ulcer caused by Helycobacter pylori, the leishmaniasis and the bacterial infections. Moreover, it is presented the rationale, the relevance and objectives of the work. In Chapter 2 is presented the results concerning the preparation of the multifunctional di(tri)thiols ligands I: bis(2-tiolethyl)amine, II:bis(2-tiolethyl)ether, III:bis(3-tiolpropyl)sulfide and IV: tris(2-tiolethyl)amine, besides their di(tri)chlorinated and di(tri)isotioureide precursors. All the compounds in question were characterized by conventional techniques such as melting point or boiling point and infrared and nuclear magnetic resonance (1H and 13C) spectroscopy. In Chapter 3 it is described the process of synthesis and characterization of the pnictogenic elements complexes with the ligands obtained with success Ia: Bi{[HN(CH2CH2S)2]Cl}, Ib: {Sb[HN(CH2CH2S)2]Cl}, IIa: {Bi[O(CH2CH2S)2]Cl}, IIb:{Sb[O(CH2CH2S)2]Cl}, IIIa: {Bi[S(CH2CH2CH2S)2]Cl} and IIIb: {Sb[S(CH2CH2CH2S)2]Cl}. The successfully obtained complexes were characterized by techniques like elemental analysis and infrared and multinuclear magnetic resonance (1H, 13C) spectroscopy. Thecrystal structures of the complexes obtained with the ligand I - Ia and Ib - were also determined by X-ray diffraction. Both series of bismuth and antimony complexes underwent initial evaluation of antibacterial activity , described in Chapter 4 . It is presented initial profiles of growthinhibiting of Gram-positive and Gram-negative bacteria, all of them human pathogens: S. aureus, L. monocytogenes, B. cereus, S. sanguinis, E. coli and S. typhimurium. Finally, Chapter 5 presents the conclusions and the perspectives obtained in the operation of this work, followed by the references and required attachments.