Efeitos do baixo volume de solução de cloreto de sódio a 0,9% isoladamente ou associada à solução de cloreto de sódio a 7,5% em coelhos submetidos a hemorragia aguda

Abstract

The hypotension is a common finding in clinical practice, both men or in pets. This condition can be caused by several factors, such as acute blood loss. The treatment of acute hemorrhage constitutes an attempt to stop the bleeding by intravenous administration of crystalloids and colloids solution, infusion of blood and hemoderivatives to restore the intravascular volume, to obtain tissue oxygenation. The aims of this study was evaluate the the effects of acute hemorrhage with permissive hipotension on macro hemodynamic parameters and renal microscopy in rabbits treated with low volume solution of sodium chloride 0.9% alone or combined with hypertonic saline 7.5%. For this study was used 12 New Zealand rabbits breed were divided into two equal groups (GH and GC), where after instrumentation and anesthesia with isoflurane was induced at acute hypovolemia. Blood was collected from the carotid artery at a rate of 20 mL / min until the MAP reached the value of 35 mmHg. After 30 minutes of blood collection, the animals were administered the GH hypertonic saline solution 7.5%, bolus volume of 4.0 ml / kg, the infusion rate of 1.0 mL / kg / min, intravenously started and after infusion of sodium chloride 0.9%, the speed of 5.0 mL / kg / h. The GC received no treatment, and solution of sodium chloride at 0.9% at the rate of 5 ml / kg / h. We evaluated the parameters of heart rate, mean arterial pressure, central venous pressure, lactate and renal histology at different times during the acute hypovolemia with permissive hypotension. No statistically significant differences were demonstrated in any parameters evaluated among the experimental groups. It is concluded in this conditions that the use of the solution of sodium chloride at 0.9% at low volume does not differ with respect to their association with saline in 7.5% NaCl in first hour of controlled acute haemorrhage at the histological renal parameters evaluated and macro hemodynamics.