Avaliação da Desmopressina no tratamento do envenenamento botrópico experimental em coelhos.

Abstract

Snakebite accidents are a serious public health problem in many regions of the world due to high morbidity and mortality. Bothrops snakes are the major species involved in ophidian accidents in Brazil, being responsible for about 90% of the cases of snakebites. Bothropic envenomation is characterized by local and systemic effects. Due to the high toxicity of the venom and the delay and/or lack of treatment with anti-bothropic serum, there may be systemic complications that predispose the patient to death. Acute kidney injury (ARI) is the most frequent complication of bothropic envenomation and is considered the leading cause of death in patients who survive the first effects of the venom. Although the pathogenesis of renal alterations in bothropic envenomation is not well defined, experimental studies suggest a multifactorial pathogenesis. The aim of this study was to evaluate the effectiveness of the treatments - antibothropic serum and desmopressin - in the first 12 hours of bothropic envenomation with a renal approach, utilizing the rabbit as an experimental model. Creatinine, urea, uric acid, total protein and fractions, glucose and phosphorus and sodium ions were evaluated. Renal tissue was evaluated macro and microscopically. Evaluating the biochemical and histopathological changes it is possible to affirm that there was renal damage, even with the institution of an early treatment.