Eficácia da Tilosina injetável (Eurofarma Laboratórios S.A.) no tratamento da enteropatia proliferativa em leitões experimentalmente inoculados

Abstract

Porcine proliferative enteropathy (PPE) is one of the most common enteric diseases in growing and finishing pigs. PPE is characterized by reduced performance, accompanied or not by diarrhea. PPE is highly prevalent in several countries of America, Europe and Asia, causing high economic losses in pig herds. The most common form of PPE control in pig herds is antibiotic therapy. The most used antimicrobials for PPE control are tylosin, chlortetracycline and tiamulin. The objective of this study was to evaluate a new product based on tylosin (Eurofarma Laboratorio S.A.) in injectable form to control PPE in experimentally inoculated animals. Sixty 5-week-old pigs with a mean weight of 9.5 kg were divided into two experimental groups of 30 animals, medicated and non-medicated. All animals were challenged with L. intracellularis, the etiologic agent of PPE, on day zero. Fecal score, body condition score and behavior were daily evaluated. Pigs were weighted on days -2, 13 and 21 after inoculation. Pigs of the medicated group received injectable tylosin 13 days after inoculation, in three doses with a 12-hour interval from each other. Pigs in non-medicated group received injectable saline solution i using the same protocol. The non-medicated group had 23 animals with diarrhea before day 13. After day 13 the number of diarrheic animals reduced to 17 animals. In the medicated group, 26 animals had diarrhea in the initial period and after medication on day 13, only 11 animals were observed with diarrhea. The score of macroscopic intestinal PPE lesions in the medicated group was lower than in the non-medicated group (p = 0.031). The medicated group also had higher score for L. intracellularis antigen by immunohistochemistry compared to the non-medicated group (p =0.032) demonstrating higher level of infection. These results demonstrate that injectable tylosin (Eurofarma Laboratories S.A.) (1mL / 20Kg) administrated in three doses, every 12 hours, was effective for the control of porcine proliferative enteropathy in experimentally inoculated pigs.