Immunolocalization of cancer stem cells marker aldh1 and its association with tumor budding in oral squamous cell carcinoma

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dc.creatorHelvécio Marangon Junior
dc.creatorVictória Vasconcellos Moreira Melo
dc.creatorÂngela Braga Caixeta
dc.creatorGiovanna Ribeiro Souto
dc.creatorPaulo Eduardo Alencar Souza
dc.creatorMaria Cassia Ferreira de Aguiar
dc.creatorMartinho Campolina Rebello Horta
dc.date.accessioned2024-08-05T20:03:40Z
dc.date.accessioned2025-09-08T23:55:51Z
dc.date.available2024-08-05T20:03:40Z
dc.date.issued2018-11-14
dc.identifier.doihttps://doi.org/10.1007/s12105-018-0985-4
dc.identifier.issn1936-0568
dc.identifier.urihttps://hdl.handle.net/1843/72642
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofHead and Neck Pathology
dc.rightsAcesso Restrito
dc.subjectAldehyde dehydrogenase 1 family
dc.subjectNeoplastic stem cells
dc.subjectMouth neoplasms
dc.subjectCarcinoma, squamous cell
dc.subjectImmunohistochemistry
dc.subjectCarcinogenesis
dc.subjectKeratins
dc.subjectAssociation
dc.subjectEvaluation study
dc.subjectPhenotype
dc.subjectGene expression
dc.subject.otherOral squamous cell carcinoma
dc.subject.otherBudding
dc.subject.otherImmunohistochemistry
dc.titleImmunolocalization of cancer stem cells marker aldh1 and its association with tumor budding in oral squamous cell carcinoma
dc.typeArtigo de periódico
local.citation.epage1e
local.citation.issueassunto cancer oral
local.citation.spage1e
local.citation.volume14 Head and neck pathology
local.description.resumoTumor budding is a prognostic marker for oral squamous cell carcinoma (OSCC) characterized by the presence of isolated or small clusters of neoplastic cells at the tumor invasive front. Aldehyde dehydrogenase-1 (ALDH1) is associated with tumorigenesis, linked to treatment resistance and shown to identify cancer stem cells (CSC)-like cells. This study aimed to evaluate the expression of ALDH1 and its association with tumor budding in OSCC. Immunohistochemistry was employed in 163 OSCC samples to identify pancytokeratin (AE1/AE3) and ALDH1. While pancytokeratin (AE1/AE3) identified squamous tumor buds, the CSC-like cells were identified using ALDH1. A Chi square test was used to evaluate association between ALDH1 expression and tumor budding, while McNemar’s test was used to identify differences in ALDH1 expression between the budding area and the area outside the budding. A positive expression of ALDH1 was observed in 47.24% of the samples and in 70% of anatomic locations affected. No association was observed between ALDH1 expression and tumor budding (p > 0.05). In tumors with high-intensity tumor budding, ALDH1 expression was higher in the budding area than in the area outside the budding (p < 0.05). The finding that tumor bud cells in OSCC show phenotypic characteristics of CSC-like cells reinforces the relevance of tumor budding in determining the biological behavior of this malignant neoplasm. Moreover, the presence of CSC-like cells in nearly half of evaluated samples of OSCC and in most of the affected anatomic locations is in accordance with the CSC model of oral carcinogenesis.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s12105-018-0985-4

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