Sociodemographic and clinical characterization of cases of 1,103 non-syndromic and 66 syndromic odontogenic keratocyst: a brazilian multicenter study

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dc.creatorDaiana Cristina Pereira Santana
dc.creatorChristany Rodrigues Ferreira
dc.creatorTatiana Nayara Libório-Kimura
dc.creatorLucileide Castro de Oliveira Moreira
dc.creatorJeconias Câmara
dc.creatorCaroline Alfaia Silva
dc.creatorElismauro Francisco de Mendonça
dc.creatorNádia do Lago Costa
dc.creatorHélder Antônio Rebelo Pontes
dc.creatorLucas Lacerda de Souza
dc.creatorJurema Freire de Castro Lisboa
dc.creatorLarissa Abbehusen Couto
dc.creatorGustavo Pina Godoy
dc.creatorJohelle de Santana Passos-Soares
dc.creatorFlávia Caló de Aquino Xavier
dc.creatorRicardo Alves de Mesquita
dc.creatorFernanda Aragão Felix
dc.creatorTarcília Aparecida da Silva
dc.creatorCassiano Francisco Weege Nonaka
dc.creatorPollianna Muniz Alves
dc.date.accessioned2025-05-20T23:55:10Z
dc.date.accessioned2025-09-09T01:34:16Z
dc.date.available2025-05-20T23:55:10Z
dc.date.issued2023-11
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1007/s00784-023-05313-7
dc.identifier.issn1436-3771
dc.identifier.urihttps://hdl.handle.net/1843/82395
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofClinical oral investigations
dc.rightsAcesso Restrito
dc.subjectOdontogenic cysts
dc.subjectMulticenter study
dc.subjectPathology, oral
dc.subjectRecurrence
dc.subjectEvaluation study
dc.subjectTherapeutics
dc.subject.otherKeratocyst
dc.subject.otherMulticenter study
dc.subject.otherOdontogenic cyst
dc.subject.otherOral pathology.
dc.titleSociodemographic and clinical characterization of cases of 1,103 non-syndromic and 66 syndromic odontogenic keratocyst: a brazilian multicenter study
dc.typeArtigo de periódico
local.citation.epage6959
local.citation.issue11
local.citation.spage6951
local.citation.volume27
local.description.resumoObjectives: This multicenter study aimed to evaluate cases of non-syndrome and syndromic odontogenic keratocyst, as well as cases of recurrence within these two groups. Methods: This descriptive, analytical, retrospective cross-sectional study evaluated the sex, age and presence of multiple lesions in 1,169 individuals seen at 10 Brazilian oral and maxillofacial pathology centers. Of these, 1,341 odontogenic keratocysts were analyzed regarding clinical diagnosis, size, site, imaging appearance, signs and symptoms, type of biopsy, treatment, and recurrence. Results: There was a similar distribution by sex. The median age of non-syndromic and syndromic patients was 32 and 17.5 years, respectively. The posterior mandible was the site most affected by small and large lesions in both groups and in recurrent cases. Unilocular lesions were more frequent, also in recurrent cases. Mainly small lesions showed this imaging appearance. Signs and symptoms were absent in most cases. Conservative treatment was the most frequent modality in all age groups, regardless of the patient's condition and recurrence. Recurrences were uncommon. Conclusion: This study showed a higher frequency of non-syndromic keratocysts in the population. Clinicopathological features related to the involvement of multiple sites, age, and recurrence may differ between syndromic and non-syndromic cases. Furthermore, we found an association between lesion size and some clinical features and between the time interval to recurrence and the syndromic spectrum. Clinical relevance: To contribute to a better understanding of the distribution and association between clinical, imaging, and sociodemographic characteristics in each spectrum of the lesion.
local.identifier.orcidhttps://orcid.org/0000-0003-4322-5405
local.identifier.orcidhttps://orcid.org/0000-0001-9623-7835
local.identifier.orcidhttps://orcid.org/0000-0003-4698-5848
local.identifier.orcidhttps://orcid.org/0000-0001-7800-8326
local.identifier.orcidhttps://orcid.org/0000-0002-3160-6967
local.identifier.orcidhttps://orcid.org/0000-0001-7260-0900
local.identifier.orcidhttps://orcid.org/0000-0002-0043-527X
local.identifier.orcidhttps://orcid.org/0000-0002-6751-3279
local.identifier.orcidhttps://orcid.org/0000-0002-3298-867X
local.identifier.orcidhttps://orcid.org/0000-0002-7609-8804
local.identifier.orcidhttps://orcid.org/0000-0002-9481-7796
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://link.springer.com/article/10.1007/s00784-023-05313-7

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