Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil

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dc.creatorIsabela M. Bensenor
dc.creatorAlessandra C. Goulart
dc.creatorAlexandre C. Pereira
dc.creatorAndré R. Brunoni
dc.creatorAirlane Alencar
dc.creatorRaul D. Santos
dc.creatorMárcio S. Bittencourt
dc.creatorRosa Weiss Telles
dc.creatorLuciana Andrade Carneiro Machado
dc.creatorSandhi Maria Barreto
dc.creatorBianca de Almeida-Pititto
dc.creatorCarolina Porto Silva Janovsky
dc.creatorJosé Augusto Sgarb
dc.creatorWilliam R. Tebar
dc.creatorVandrize Meneghini
dc.creatorFernando Barbosa Junior
dc.creatorAna Cristina de Medeiros Ribeiro
dc.creatorSandra Gofinet Pasoto
dc.creatorRosa Maria R. Pereira
dc.creatorEloísa Bonfá
dc.creatorAytan M. Sipahi
dc.creatorItamar de S. Santos
dc.creatorPaulo A. Lotufo
dc.date.accessioned2024-06-18T15:54:59Z
dc.date.accessioned2025-09-08T23:43:29Z
dc.date.available2024-06-18T15:54:59Z
dc.date.issued2022
dc.identifier.doihttps://doi.org/10.1016/j.clinsp.2022.100013
dc.identifier.issn1807-5932
dc.identifier.urihttps://hdl.handle.net/1843/69260
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofClinics
dc.rightsAcesso Aberto
dc.subjectDoença crônica
dc.subjectDoenças cardiovasculares
dc.subjectEspessura intima-media carotídea
dc.subjectAterosclerose
dc.subject.otherChronic Inflammatory disease
dc.subject.otherCardiovascular disease
dc.subject.otherCoronary artery calcium (CAC)
dc.subject.otherCarotid intima-media thickness (CIMT)
dc.subject.otherFatal and non-fatal cardiovascular events
dc.titleChronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil
dc.typeArtigo de periódico
local.citation.volume77
local.description.resumoObjectives: This analysis describes the protocol of a study with a case-cohort to design to prospectively evaluate the incidence of subclinical atherosclerosis and Cardiovascular Disease (CVD) in Chronic Inflammatory Disease (CID) participants compared to non-diseased ones. Methods: A high-risk group for CID was defined based on data collected in all visits on self-reported medical diagnosis, use of medicines, and levels of high-sensitivity C-Reactive Protein >10 mg/L. The comparison group is the Aleatory Cohort Sample (ACS): a group with 10% of participants selected at baseline who represent the entire cohort. In both groups, specific biomarkers for DIC, markers of subclinical atherosclerosis, and CVD morbimortality will be tested using weighted Cox. Results: The high-risk group (n = 2,949; aged 53.6 ± 9.2; 65.5% women) and the ACS (n=1543; 52.2±8.8; 54.1% women) were identified. Beyond being older and mostly women, participants in the high-risk group present low average income (29.1% vs. 24.8%, p < 0.0001), higher BMI (Kg/m2) (28.1 vs. 26.9, p < 0.0001), higher waist circumference (cm) (93.3 vs. 91, p < 0.0001), higher frequencies of hypertension (40.2% vs. 34.5%, p < 0.0001), diabetes (20.7% vs. 17%, p = 0.003) depression (5.8% vs. 3.9%, p = 0.007) and higher levels of GlycA a new inflammatory marker (p < 0.0001) compared to the ACS. Conclusions: The high-risk group selected mostly women, older, lower-income/education, higher BMI, waist circumference, and of hypertension, diabetes, depression, and higher levels of GlycA when compared to the ACS. The strategy chosen to define the high-risk group seems adequate given that multiple sociodemographic and clinical characteristics are compatible with CID.
local.identifier.orcidhttp://orcid.org/0000-0003-4027-2943
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE MEDICINA PREVENTIVA SOCIAL
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1807593222000096?via%3Dihub

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