Evaluation of the prevalence and factors associated with acute kidney injury in a pediatric intensive care unit

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dc.creatorCibelle Ferreira Louzada
dc.creatorAlexandre Rodrigues Ferreira
dc.date.accessioned2024-07-03T22:17:38Z
dc.date.accessioned2025-09-09T01:16:51Z
dc.date.available2024-07-03T22:17:38Z
dc.date.issued2021
dc.format.mimetypepdf
dc.identifier.doi10.1016/j.jped.2020.08.003
dc.identifier.issn0021-7557
dc.identifier.urihttps://hdl.handle.net/1843/69645
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJornal de Pediatria
dc.rightsAcesso Aberto
dc.subjectInjúria Renal Aguda
dc.subjectUnidades de Terapia Intensiva Pediátrica
dc.subjectCuidados Críticos
dc.subjectCriança
dc.subject.otherlesão renal aguda
dc.subject.otherTerapia Intensiva
dc.subject.otherCrianças e Adolescente
dc.titleEvaluation of the prevalence and factors associated with acute kidney injury in a pediatric intensive care unit
dc.typeArtigo de periódico
local.citation.epage432
local.citation.issue4
local.citation.spage426
local.citation.volume97
local.description.resumoObjective: To assess the prevalence of acute kidney injury in pediatric intensive care unit according to diagnostic criteria - pediatric risk, injury, failure, loss, end-stage renal disease, Acute Kidney Injury Network and Acute Kidney Injury Work Group, or Kidney Disease: Improving Global Outcomes -, and determining factors associated with acute kidney injury as well as its outcome. Methodology: This was a cross-sectional monocentric observational study, including patients aged between 29 days and 17 years who were admitted to the pediatric intensive care unit between January 1, 2012 and December 31, 2016. To evaluate the association between the study variables and acute kidney injury, the log-binomial generalized univariate and multivariate linear models were adjusted. Results: The study included 1131 patients, with prevalence of acute kidney injury according to the Acute Kidney Injury Network and Kidney Disease: Improving Global Outcomes criteria of 12.6% and of 12.9% according to the pediatric risk, injury, failure, loss, end-stage renal disease. In the multivariate analysis of older children (PR 1.007, 95% CI: 1.005-1.009), sepsis (PR 1.641, 95% CI: 1.128-2.387), demand for ventilatory support (PR 1.547, 95% CI: 1.095-2.186), and use of vasoactive amines (PR 2.298, 95% CI: 1.681-3.142) constituted factors associated with statistical significance to the development of acute kidney injury. The mortality rate among those with acute kidney injury was 28.7%. Conclusion: Older children, diagnosis of sepsis, demand for ventilatory support, and use of vasoactive amines were correlated with a higher risk of developing acute kidney injury. The mortality associated with acute kidney injury was elevated; it is crucial that all measures that ensure adequate renal perfusion are taken for patients with risk factors, to avoid the installation of the disease.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/jped/a/sTmNbmzwDTPBwPbzyPZdphQ/?lang=en

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