Exercise tests in chagas cardiomyopathy: an overview of functional evaluation, prognostic significance, and current challenges

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dc.creatorHenrique Silveira Costa
dc.creatorMauro Felippe Felix Mediano
dc.creatorManoel Otávio da Costa Rocha
dc.creatorMárcia Maria Oliveira Lima
dc.creatorPedro Henrique Scheidt Figueiredo
dc.creatorVanessa Pereira Lima
dc.creatorMatheus Ribeiro Ávila
dc.creatorKenia Kiefer Parreiras de Menezes
dc.creatorVanessa Amaral Mendonça
dc.creatorAna Cristina Rodrigues Lacerda
dc.creatorMaria Carmo Pereira Nunes
dc.date.accessioned2024-01-10T21:41:09Z
dc.date.accessioned2025-09-08T22:53:19Z
dc.date.available2024-01-10T21:41:09Z
dc.date.issued2020
dc.format.mimetypepdf
dc.identifier.doi10.1590/0037-8682-0100-2020
dc.identifier.issn16789849
dc.identifier.urihttps://hdl.handle.net/1843/62556
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofRevista da Sociedade Brasileira de Medicina Tropical
dc.rightsAcesso Aberto
dc.subjectChagas disease
dc.subjectChagas cardiomyopathy
dc.subjectExercise test
dc.subjectExercise Tolerance
dc.subjectHealth Evaluation
dc.subjectPrognosis
dc.subject.otherChagas disease
dc.subject.otherChagas cardiomyopathy
dc.subject.otherExercise test
dc.subject.otherExercise Tolerance
dc.subject.otherEvaluation
dc.subject.otherPrognosis
dc.titleExercise tests in chagas cardiomyopathy: an overview of functional evaluation, prognostic significance, and current challenges
dc.typeArtigo de periódico
local.citation.epage10
local.citation.issue(e20200100)
local.citation.spage1
local.citation.volume53
local.description.resumoPatients with Chagas cardiomyopathy (ChC) usually progress with fatigue and dyspnea. Exercise tests are valuable for the functional evaluation of these patients. However, information about the applicability of the exercise tests is scattered, and no studies have systematically reviewed the results. Thus, the present review explored the general aspects and prognostic value of exercise tests in patients with ChC. A literature search of the MEDLINE, Web of Science, CINAHL, Scopus, and LILACS databases was performed to identify relevant studies. There were no data restrictions, and articles that met the objective of the study were selected. Articles written in English, Portuguese, and Spanish were considered, and 25 articles were finally included. The peak oxygen uptake (VO2peak) was correlated with demographic and echocardiographic variables. Echocardiographic features of the left ventricular diastolic function and right ventricular systolic function appeared to be determinants of functional capacity, in addition to age and sex. VO2peak was associated with higher mortality, especially in patients with dilated ChC. The minute ventilation/carbon dioxide production slope (VE/VCO2 slope) was a strong predictor of survival; however, more studies are needed to verify this observation. Field tests showed moderate to strong correlation with VO2peak and thus may be inexpensive tools for the functional evaluation of patients with ChC. However, few studies have verified their prognostic significance. While exercise tests are useful tools for functional assessment, information is scarce regarding further considerations, and many of the criteria are based on guidelines for other heart diseases.
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://doi.org/10.1590/0037-8682-0100-2020

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