EDTA-dependent pseudothrombocytopenia in patients with hepatosplenic schistosomiasis mansoni: a clinical management alert

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dc.creatorGuilherme Vaz de Melo Trindade
dc.creatorJúlia Fonseca de Morais Caporali
dc.creatorDebora Vaz de Melo Trindade
dc.creatorSilvana Junia Roriz
dc.creatorThiago Almeida Pereira
dc.creatorPatrícia Donado Vaz de Melo
dc.creatorJosé Roberto Lambertucci
dc.date.accessioned2023-08-10T20:17:19Z
dc.date.accessioned2025-09-09T00:49:02Z
dc.date.available2023-08-10T20:17:19Z
dc.date.issued2021-02-15
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1093/trstmh/trab034
dc.identifier.issn0035-9203
dc.identifier.urihttps://hdl.handle.net/1843/57713
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofTransactions of The Royal Society of Tropical Medicine and Hygiene
dc.rightsAcesso Restrito
dc.subjectEsquistossomose mansoni
dc.subjectContagem de Plaquetas
dc.subjectCitrato de Sódio
dc.subject.otherEDTA
dc.subject.otherSchistosomiasis mansoni
dc.subject.otherPlatelet count
dc.subject.otherPseudothrombocytopenia
dc.subject.otherSodium citrate
dc.titleEDTA-dependent pseudothrombocytopenia in patients with hepatosplenic schistosomiasis mansoni: a clinical management alert
dc.typeArtigo de periódico
local.citation.epage6
local.citation.spage1
local.citation.volume1
local.description.resumoplatelet counts are required for identification and management of HS patients. EDTA-dependent pseudothrombocytopenia (EDTA-PTCP) is an in vitro phenomenon of anticoagulant-activated platelet agglutination resulting in low platelet counts by automated methods. The prevalence of EDTA-PCTP in schistosomiasis is unknown and only one case has been described. Our aims were to determine the prevalence of EDTA-PTCP in HS and evaluate alternative methods to overcome this analytical error. Methods: Blood samples from 56 HS patients and 56 healthy volunteers were collected, and platelet counts were obtained using standard microscopy and automated (electric impedance) methods. Automated platelet counts and the presence of platelet clumps in blood smears were evaluated in samples collected in EDTA or sodium citrate tubes 20 and 180 min after blood collection. Results: EDTA-PTCP was more frequent in HS patients than healthy volunteers (8.92% vs 0.00%, p<0.0285). Platelet clumps and PTCP were also observed in samples collected in sodium citrate tubes, refuting its use as an alternative method. Conclusions: Automated platelet counts in blood samples from HS patients should be performed right after blood collection in EDTA tubes and verified by manual counts in blood smears.
local.identifier.orcidhttps://orcid.org/0000-0003-0544-309X
local.publisher.countryBrasil
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.initialsUFMG
local.url.externahttps://academic.oup.com/trstmh/article/115/10/1168/6159779?login=true

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