Aerobic training efficacy in inflammation, neurotrophins, and function in chronic stroke persons: a randomized controlled trial protocol

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dc.creatorDaniela Matos Garcia Oliveira
dc.creatorLarissa Tavares Aguiar
dc.creatorMarcus Vinícius de Oliveira Limones
dc.creatorAline Gonçalves Gomes
dc.creatorLuana Cristina da Silva
dc.creatorChristina Danielli Coelho de Morais
dc.creatorPaula Luciana Scalzo
dc.date.accessioned2022-12-20T14:24:08Z
dc.date.accessioned2025-09-09T00:28:08Z
dc.date.available2022-12-20T14:24:08Z
dc.date.issued2019-02
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.identifier.doihttps://doi.org/10.1016/j.jstrokecerebrovasdis.2018.10.016
dc.identifier.issn1532-8511
dc.identifier.urihttps://hdl.handle.net/1843/48247
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Stroke and Cerebrovascular Diseases
dc.rightsAcesso Restrito
dc.subjectFator neurotrófico derivado do cérebro
dc.subjectExercícios aeróbicos
dc.subjectInflamação
dc.subjectAcidente vascular cerebral
dc.subject.otherAerobic exercise
dc.subject.otherInflammation
dc.subject.otherBDNF
dc.subject.otherStroke
dc.titleAerobic training efficacy in inflammation, neurotrophins, and function in chronic stroke persons: a randomized controlled trial protocol
dc.typeArtigo de periódico
local.citation.epage424
local.citation.issue2
local.citation.spage418
local.citation.volume28
local.description.resumoBackground: Neuroinflammation is an important part of stroke pathophysiology and has both detrimental and beneficial effects after stroke. Besides that the enhancement of neurotrophins seems to be related to improvements in stroke recovery. Evidences suggest that exercise plays a role in modulating anti-inflammatory and neurotrophic effects. However, little is known about its impact in stroke survivors, mainly in chronic stroke. The purpose of this study is to investigate the efficacy of moderate-intensity treadmill exercise in changing inflammatory mediators, interleukin-6 (IL-6), soluble tumor necrosis factor receptors I and II (sTNFRI, sTNFRII), interleukin-10 (IL-10), and brain-derived neurotrophic factor (BDNF) levels in chronic stroke patients. The secondary objective is to investigate the effects of training in improve mobility and exercise capacity. Methods: This is a randomized controlled trial. Chronic stroke patients will be randomized to an experimental or control group, and will receive group interventions three times per week, over 12 weeks. The experimental group will receive moderate-intensity (60%-80% of maximum heart rate reserve) treadmill exercise. Control group will perform walking training on the ground (<40% of maximum heart rate reserve). Primary outcomes include IL-6, sTNFRI, sTNFRII, IL-10, and BDNF levels. Secondary outcomes include mobility and exercise capacity. Outcomes will be measured at baseline, postintervention, and at the 4-week follow-up. Discussion: The findings of this trial have the potential to provide important insights regarding the effects of an aerobic physical program in the inflammatory process and in the neuronal plasticity in stroke persons and its impact on mobility and exercise capacity.
local.identifier.orcidhttps://orcid.org/0000-0002-6503-774X
local.identifier.orcidhttps://orcid.org/0000-0001-9784-9729
local.identifier.orcidhttp://orcid.org/0000-0003-1383-8550
local.publisher.countryBrasil
local.publisher.departmentEEF - DEPARTAMENTO DE FISIOTERAPIA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S1052305718305962?via%3Dihub

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