4-Methylbenzenecarbothioamide, a hydrogen sulfide donor, inhibits tumor necrosis factor-α and CXCL1 production and exhibits activity in models of pain and inflammation

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dc.creatorIvo Souza Ferraz de Melo
dc.creatorFlávio Almeida Amaral
dc.creatorRenata Barbosa Oliveira
dc.creatorÂngelo de Fátima
dc.creatorMárcio de Matos Coelho
dc.creatorRenes de Resende Machado
dc.creatorFelipe Fernandes Rodrigues
dc.creatorSarah Olivia Alves Mendes da Costa
dc.creatorAlysson Vinícius Braga
dc.creatorMarcela Ísis Morais
dc.creatorJéssica Aparecida Vaz
dc.creatorLeonardo da Silva Neto
dc.creatorIzabela Galvão
dc.creatorLuzia Valentina Modolo
dc.date.accessioned2024-10-07T21:12:45Z
dc.date.accessioned2025-09-09T00:28:31Z
dc.date.available2024-10-07T21:12:45Z
dc.date.issued2019
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico
dc.description.sponsorshipFAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
dc.description.sponsorshipOutra Agência
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1016/j.ejphar.2019.172404
dc.identifier.issn0014-2999
dc.identifier.urihttps://hdl.handle.net/1843/77286
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofEuropean Journal of Pharmacology
dc.rightsAcesso Aberto
dc.subjectDor
dc.subjectInflamação
dc.subjectFator de necrose de tumor
dc.subjectAgentes antiinflamatórios
dc.subjectMinerais de sulfeto
dc.subjectHidrogênio
dc.subject.otherHydrogen sulfide
dc.subject.other4-Methylbenzenecarbothioamide
dc.subject.otherPain
dc.subject.otherInflammation
dc.subject.otherTumor necrosis factor-α
dc.subject.otherCXCL-1
dc.title4-Methylbenzenecarbothioamide, a hydrogen sulfide donor, inhibits tumor necrosis factor-α and CXCL1 production and exhibits activity in models of pain and inflammation
dc.typeArtigo de periódico
local.citation.spage172404
local.citation.volume856
local.description.resumoThe gasotransmitter hydrogen sulfide (H2S) is known to regulate many pathophysiological processes. Preclinical assays have demonstrated that H2S donors exhibit anti-inflammatory and antinociceptive activities, characterized by reduction of inflammatory mediators production, leukocytes recruitment, edema and mechanical allodynia. In the present study, the effects induced by 4-methylbenzenecarbothioamide (4-MBC) in models of pain and inflammation in mice, the mechanisms mediating such effects and the H2S-releasing property of this compound were evaluated. 4-MBC spontaneously released H2S in vitro in the absence of organic thiols. Intraperitoneal (i.p.) administration of 4-MBC (100 or 150 mg/kg) reduced the second phase of the nociceptive response induced by formaldehyde and induced a long lasting inhibitory effect on carrageenan mechanical allodynia. 4-MBC antiallodynic effect was not affected by previous administration of naltrexone or glibenclamide. 4-MBC (50, 100 or 150 mg/kg, i.p.) induced a long lasting inhibitory effect on paw edema induced by carrageenan. The highest dose (150 mg/kg, i.p.) of 4-MBC inhibited tumor necrosis factor-α and CXCL1 production and myeloperoxidase activity induced by carrageenan. Mechanical allodynia and paw edema induced by carrageenan were not inhibited by the 4-MBC oxo analogue (p-toluamide). In summary, 4-MBC, an H2S releasing thiobenzamide, exhibits antinociceptive and anti-inflammatory activities. These activities may be due to reduced cytokine and chemokine production and neutrophil recruitment. The H2S releasing property is likely essential for 4-MBC activity. Our results indicate that 4-MBC may represent a useful pharmacological tool to investigate the biological roles of H2S.
local.identifier.orcidhttps://orcid.org/0000-0002-1695-0612
local.identifier.orcidhttps://orcid.org/0000-0003-2344-5590
local.identifier.orcidhttps://orcid.org/0000-0001-5884-2567
local.identifier.orcidhttps://orcid.org/0000-0002-1284-1195
local.identifier.orcidhttps://orcid.org/0000-0001-7732-9988
local.identifier.orcidhttps://orcid.org/0000-0003-4554-9577
local.identifier.orcidhttps://orcid.org/0000-0002-8033-0434
local.publisher.countryBrasil
local.publisher.departmentFAR - DEPARTAMENTO DE PRODUTOS FARMACÊUTICOS
local.publisher.departmentICB - DEPARTAMENTO DE BIOQUÍMICA E IMUNOLOGIA
local.publisher.departmentICB - DEPARTAMENTO DE BOTÂNICA
local.publisher.departmentICX - DEPARTAMENTO DE QUÍMICA
local.publisher.initialsUFMG
local.url.externahttps://www.sciencedirect.com/science/article/pii/S0014299919303474

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