Prognostic importance of fgf2 and fgfr1 expression for patients affected by ameloblastoma

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dc.creatorFelipe Paiva Fonseca
dc.creatorBernar Monteiro Benites
dc.creatorCiro Dantas Soares
dc.creatorThayna Melo de Lima Morais
dc.creatorGleyson Kleber do Amaral Silva
dc.creatorOslei Paes de Almeida
dc.creatorFernando Augusto Soares
dc.creatorEduardo Rodrigues Fregnani
dc.date.accessioned2023-10-26T18:33:09Z
dc.date.accessioned2025-09-08T23:04:14Z
dc.date.available2023-10-26T18:33:09Z
dc.date.issued2018
dc.identifier.doihttps://doi.org/10.1111/jop.12695
dc.identifier.issn09042512
dc.identifier.urihttps://hdl.handle.net/1843/60097
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.rightsAcesso Restrito
dc.subjectAmeloblastoma
dc.subjectFibroblast growth factors
dc.subjectReceptors, fibroblast growth factor
dc.subjectOdontogenic tumors
dc.subjectCytoplasm
dc.subjectSurvival rate
dc.subject.otherPrognostic importance of fgf2 and fgfr1 expression for patients affected by ameloblastoma busca dia 13 do 09 ano 2023 restrito assunto ameloblastoma
dc.titlePrognostic importance of fgf2 and fgfr1 expression for patients affected by ameloblastoma
dc.typeArtigo de periódico
local.citation.epage424
local.citation.issue4
local.citation.spage417
local.citation.volume47
local.description.resumoBackground: Fibroblast growth factor 2 (FGF2) and FGF receptor 1 (FGFR1) have been investigated in different human neoplasms and were shown to play important roles in the pathogenesis of these diseases; however, very few are known regarding their prognostic importance in the context of ameloblastoma. Therefore, the aim of this study was to investigate whether the expression of FGF2 and FGFR1 is associated with ameloblastoma clinical behavior. Methods: Fifty-eight cases of ameloblastoma arranged in tissue microarray were submitted to immunohistochemistry against FGF2 and FGFR1. Clinicopathological parameters regarding sex, age, tumor size, duration and location, treatment, recurrences, radiographic features, cortical disruptions, and follow-up data were obtained from patients' medical records and correlated with the molecules expression. Univariate and multivariate Cox regression analyses were used to investigate the prognostic potential of the biomarkers. Results: Forty-four cases (75.9%) exhibited cytoplasmic positivity for FGF2 in central and peripheral epithelial cells, 46 of 58 (79.3%) showed FGFR1 cytoplasmic positivity predominantly in the columnar peripheral cells, and 43 cases (74.1%) were positive for both. Expression of FGF2 and FGF2 + FGFR1 was associated with tumor recurrences (P = .05). However, univariate and multivariate analyses did not demonstrate a significant influence of FGF2, FGFR1, or FGF2 + FGFR1 in the 5-year disease-free survival (DFS) rate (P = .27, P = .33, and P = .25, respectively). Conclusion: Cytoplasmic expression of FGF2 and FGF2 + FGFR1 is associated with ameloblastoma recurrence, but FGF2 and FGFR1 are not determinants of a lower DFS.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE CLÍNICA
local.publisher.initialsUFMG
local.url.externahttps://onlinelibrary.wiley.com/doi/10.1111/jop.12695

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