Lack of Association between Genetic Polymorphism of Circadian Genes (PER2, PER3, CLOCK and OX2R) with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population (Circadian Genes, Late-Onset Depression and Alzheimer's Disease)

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dc.creatorDebora Miranda
dc.creatorPatriciapereira
dc.creatorAntônio Marcos Alvim Soares Júnior
dc.creatorMaria Bicalho
dc.creatorEdgar de Moraes
dc.creatorLeandro Malloy-diniz
dc.creatorJonas de Paula
dc.creatorMarco Romano-silva
dc.date.accessioned2023-07-27T21:34:43Z
dc.date.accessioned2025-09-08T23:47:19Z
dc.date.available2023-07-27T21:34:43Z
dc.date.issued2016-04-27
dc.format.mimetypepdf
dc.identifier.doi10.2174/1567205013666160603005630
dc.identifier.issn15672050
dc.identifier.urihttps://hdl.handle.net/1843/57104
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofCurrent Alzheimer Research
dc.rightsAcesso Restrito
dc.subjectPolimorfismo de Nucleotídeo Único
dc.subjectDoença de Alzheimer
dc.subjectHomologia de Sequência
dc.subjectProteínas CLOCK
dc.subjectReceptores de Orexina
dc.subject.otherSingle-nucleotide polymorphism
dc.subject.otherLate-onset depression
dc.subject.otherAlzheimer’s Disease
dc.subject.otherPeriod Homolog
dc.subject.otherCLOCK
dc.subject.otherOrexin Receptor 2
dc.titleLack of Association between Genetic Polymorphism of Circadian Genes (PER2, PER3, CLOCK and OX2R) with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population (Circadian Genes, Late-Onset Depression and Alzheimer's Disease)
dc.typeArtigo de periódico
local.citation.epage1
local.citation.issue999
local.citation.spage1
local.citation.volume13
local.description.resumoAbstract: Objectives: This study aims to evaluate the association between polymorphisms in circadian genes and Alzheimer’s disease (AD) and/or late-onset de pression (LOD). AD pathology leads to circadian disturbances, with clear negative influence on quality of life. In addition, there is an increasing evidence that regulators of circadian system have effects on AD and LOD pathology. Design and Subjects: An exploratory case-control study designed to evaluate SNPs in the PER2, PER3, CLOCK and OX2R genes in a sample composed by 249 AD, 222 LOD and 112 healthy individuals. Measures: The participants were evaluated using DSM-IV criteria for LOD and NINCDS-ADRDA for AD. Results: In allelic analysis, the OX2R SNP, rs2134294, showed an association of allele C with LOD (p =0.02, OR= 1.6) and AD (p=0.04, OR =1.5). The rs2134294 also showed a genotypic association C/C (p =0.01) for higher risk to develop LOD compared to the control group, with an odd’s ratio of 2.7. The rs9370399 (OX2R) has also shown an association between A allele (p=0.03, OR= 1.4) and AD. These results do not persist after a 1,000 permutations test. For other markers of the OX2R gene and for all other markers of this study no association was found. Conclusion: In conclusion, the present study found that the investigated Circadian Genes (PER2, PER3, CLOCK and OX2R) polymorphisms were not associated with LOD or AD.
local.identifier.orcid0000-0002-9649-867X
local.publisher.countryBrasil
local.publisher.departmentFAF - DEPARTAMENTO DE PSICOLOGIA
local.publisher.departmentMED - DEPARTAMENTO DE CLÍNICA MÉDICA
local.publisher.departmentMED - DEPARTAMENTO DE PEDIATRIA
local.publisher.departmentMED - DEPARTAMENTO DE SAÚDE MENTAL
local.publisher.initialsUFMG
local.url.externahttps://www.ingentaconnect.com/contentone/ben/car/2016/00000013/00000012/art00011

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