Cytotoxicity and biocompatibility of a new bioceramic endodontic sealer containing calcium hydroxide

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dc.creatorFrancine Benetti
dc.creatorÍndia Olinta de Azevedo Queiroz
dc.creatorPedro Henrique Chaves de Oliveira
dc.creatorLeticia Citelli Conti
dc.creatorMariane Maffei Azuma
dc.creatorSandra Helena Penha de Oliveira
dc.creatorLuciano Tavares Ângelo Cintra
dc.date.accessioned2022-09-30T19:20:31Z
dc.date.accessioned2025-09-08T23:28:24Z
dc.date.available2022-09-30T19:20:31Z
dc.date.issued2019-05-16
dc.description.sponsorshipFAPESP - Fundação de Amparo à Pesquisa do Estado de São Paulo
dc.format.mimetypepdf
dc.identifier.doihttps://doi.org/10.1590/1807-3107bor-2019.vol33.0042
dc.identifier.issn18073107
dc.identifier.urihttps://hdl.handle.net/1843/45824
dc.languageeng
dc.publisherUniversidade Federal de Minas Gerais
dc.relation.ispartofBrazilian Oral Research
dc.rightsAcesso Aberto
dc.subjectEndodontics
dc.subjectMaterials testing
dc.subjectInflammation
dc.subjectCell culture techniques
dc.subject.otherCell culture techniques
dc.subject.otherEndodontics
dc.subject.otherInflammation
dc.subject.otherMaterials testing
dc.titleCytotoxicity and biocompatibility of a new bioceramic endodontic sealer containing calcium hydroxide
dc.typeArtigo de periódico
local.citation.epage9
local.citation.spage1
local.citation.volume33
local.description.resumoThis study evaluated the cytotoxicity and biocompatibility of a new bioceramic endodontic sealer (i.e., Sealer Plus BC) in comparison with those of MTA Fillapex and AH Plus. L929 fibroblasts were cultured and Alamar Blue was used to evaluate cell viability of diluted extracts (1:50, 1:100, and 1:200) from each sealer at 24 h. Polyethylene tubes that were filled with material or empty (as a control) were implanted in the subcutaneous tissue of rats. The rats were killed after 7 and 30 d (n = 8), and the tubes were removed for histological analysis. Parametric data was analyzed using a one-way ANOVA test, and nonparametric data was analyzed via the Kruskal–Wallis test followed by the Dunn test (p < 0.05). A reduction in cell viability was observed in the extracts that were more diluted for Sealer Plus BC when compared to that of Control and AH Plus (p < 0.05). However, the 1:50 dilution of the Sealer Plus BC was similar to that of the Control (p > 0.05). Conversely, more diluted extracts of MTA Fillapex (1:200) and AH Plus (1:100 and 1:200) were similar to the Control (p > 0.05). Histological analysis performed at 7 d did not indicate any significant difference between tissue response for all materials, and the fibrous capsule was thick (p > 0.05). At 30 d, Sealer Plus BC was similar to the Control (p > 0.05) and MTA Fillapex and AH Plus exhibited greater inflammation than the Control (p < 0.05). The fibrous capsule was thin for the Control and for most specimens of Sealer Plus BC and AH Plus. Thus, Sealer Plus BC is biocompatible when compared to MTA Fillapex and AH Plus, and it is less cytotoxic when less-diluted extracts are used.
local.publisher.countryBrasil
local.publisher.departmentFAO - DEPARTAMENTO DE ODONTOLOGIA RESTAURADORA
local.publisher.initialsUFMG
local.url.externahttps://www.scielo.br/j/bor/a/DhsNtpyxZQPtsndgXwpybDB/?lang=en

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